The abstracts presented at the 2018 International Society for Extracellular Vesicles Annual Meeting offer unique insight into the newest discoveries related to the biology and applied use of extracellular vesicles (EVs). As an extension of a recent “Clinical-Wrap Up” discussion at the International Society for Extracellular Vesicles 2018 Annual Meeting, a systematic review of each abstract was performed to determine which abstracts could be considered clinical research. Once the clinical research abstracts were identified, systematic data extraction included: the major focus of each clinical research abstract; the countries in which the work was done; and the sample size, if provided in the abstract. Each abstract was reviewed by two independent authors, with a third author resolving discrepancies in cases of disagreement. 174 out of 656 (27%) unique abstracts were determined to be clinical research. Oncology was a principal research focus (51 of the 174 clinical research abstracts, 29%). Many other clinical research abstracts presented at the International Society for Extracellular Vesicles 2018 Annual Meeting focused on the use of human samples for development of methods for potential application in the clinic. Beyond oncology and methods development, a wide range of topics was represented, including cardiovascular disease, neurodegenerative disease, genetics, and many others. Current research involving EVs highlights the common, but false dichotomy of science into curiosity-driven basic science or application-driven clinical research, when in fact both quest for understanding and intent to apply the findings appeared to drive much of the work at the International Society for Extracellular Vesicles 2018 Annual Meeting. Using Pasteur’s Quadrant as a framework, we discuss where the field of EV research is heading and how we may gain insight into the biological function of EVs in tandem with how they may benefit individual health.

2018 年国际细胞外囊泡学会年会上发表的摘要提供了对细胞外囊泡 (EV) 生物学和应用相关最新发现的独特见解。作为最近在国际细胞外囊泡学会 2018 年年会上进行的“临床总结”讨论的延伸，对每个摘要进行了系统审查，以确定哪些摘要可以被视为临床研究。一旦确定了临床研究摘要，系统性的数据提取包括： 每个临床研究摘要的主要焦点；工作完成的国家；以及样本量（如果在摘要中提供）。每份摘要均由两位独立作者审阅，第三位作者解决分歧的情况。656 份独特摘要中的 174 份 (27%) 被确定为临床研究。肿瘤学是主要研究重点（174 份临床研究摘要中的 51 份，占 29%）。在国际细胞外囊泡学会 2018 年年会上提出的许多其他临床研究摘要重点关注使用人体样本来开发临床潜在应用的方法。除了肿瘤学和方法开发之外，会议还涉及广泛的主题，包括心血管疾病、神经退行性疾病、遗传学等。目前涉及电动汽车的研究强调了科学的常见但错误的二分法，即好奇心驱动的基础科学或应用驱动的临床研究，而事实上，寻求理解和应用研究结果的意图似乎推动了国际协会的大部分工作细胞外囊泡2018年年会。使用巴斯德象限作为框架，我们讨论了电动汽车研究领域的发展方向，以及我们如何深入了解电动汽车的生物学功能以及它们如何有益于个人健康。