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Predictive significance of CYFRA21-1, squamous cell carcinoma antigen and carcinoembryonic antigen for lymph node metastasis in patients with esophageal squamous cancer.
The International Journal of Biological Markers ( IF 2.3 ) Pub Date : 2019-05-15 , DOI: 10.1177/1724600819847999
Xinyu Mei 1 , Xiaodong Zhu 1 , Lei Zuo 1 , Hanran Wu 1 , Mingfa Guo 1 , Changqing Liu 1
Affiliation  

From January 2018 to May 2018, 108 patients with thoracic esophageal cancer underwent esophagectomy with two- to three-field lymph node dissection. Serum cytokeratin 19 fragment antigen 21-1 (CYFRA21-1), squamous cell carcinoma antigen, and carcinoembryonic antigen levels were detected before surgery. Preoperative serum levels of CYFRA21-1 and squamous cell carcinoma antigen were correlated closely with pN stage (P = 0.000 and P = 0.045). CYFRA21-1 and pathological T status were independent predictors of lymph node metastasis (P = 0.000). The area under the curve values of CYFRA21-1 and squamous cell carcinoma antigen for predicting lymph node metastasis were 0.731 (P =0.000) and 0.650 (P =0.007), respectively. Our study demonstrated that serum CYFRA21-1 and squamous cell carcinoma antigen levels were associated with lymph node metastasis in esophageal squamous cell carcinoma, especially in patients at the early T stage. The preoperative serum CYFRA21-1 level was an independent predictor of lymph node metastasis.

中文翻译:

CYFRA21-1,鳞状细胞癌抗原和癌胚抗原对食管鳞癌患者淋巴结转移的预测意义。

从2018年1月至2018年5月,对108例胸段食管癌患者进行了2至3场淋巴结清扫术。术前检测血清细胞角蛋白19片段抗原21-1(CYFRA21-1),鳞状细胞癌抗原和癌胚抗原水平。术前血清CYFRA21-1和鳞状细胞癌抗原的水平与pN分期密切相关(P = 0.000和P = 0.045)。CYFRA21-1和病理性T状态是淋巴结转移的独立预测因子(P = 0.000)。CYFRA21-1和鳞状细胞癌抗原的曲线值下预测淋巴结转移的面积分别为0.731(P = 0.000)和0.650(P = 0.007)。我们的研究表明,血清CYFRA21-1和鳞状细胞癌抗原水平与食管鳞状细胞癌的淋巴结转移有关,特别是在T早期的患者。术前血清CYFRA21-1水平是淋巴结转移的独立预测因子。
更新日期:2019-11-01
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