From January 2018 to May 2018, 108 patients with thoracic esophageal cancer underwent esophagectomy with two- to three-field lymph node dissection. Serum cytokeratin 19 fragment antigen 21-1 (CYFRA21-1), squamous cell carcinoma antigen, and carcinoembryonic antigen levels were detected before surgery. Preoperative serum levels of CYFRA21-1 and squamous cell carcinoma antigen were correlated closely with pN stage (P = 0.000 and P = 0.045). CYFRA21-1 and pathological T status were independent predictors of lymph node metastasis (P = 0.000). The area under the curve values of CYFRA21-1 and squamous cell carcinoma antigen for predicting lymph node metastasis were 0.731 (P =0.000) and 0.650 (P =0.007), respectively. Our study demonstrated that serum CYFRA21-1 and squamous cell carcinoma antigen levels were associated with lymph node metastasis in esophageal squamous cell carcinoma, especially in patients at the early T stage. The preoperative serum CYFRA21-1 level was an independent predictor of lymph node metastasis.

中文翻译：

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CYFRA21-1，鳞状细胞癌抗原和癌胚抗原对食管鳞癌患者淋巴结转移的预测意义。

从2018年1月至2018年5月，对108例胸段食管癌患者进行了2至3场淋巴结清扫术。术前检测血清细胞角蛋白19片段抗原21-1（CYFRA21-1），鳞状细胞癌抗原和癌胚抗原水平。术前血清CYFRA21-1和鳞状细胞癌抗原的水平与pN分期密切相关（P = 0.000和P = 0.045）。CYFRA21-1和病理性T状态是淋巴结转移的独立预测因子（P = 0.000）。CYFRA21-1和鳞状细胞癌抗原的曲线值下预测淋巴结转移的面积分别为0.731（P = 0.000）和0.650（P = 0.007）。我们的研究表明，血清CYFRA21-1和鳞状细胞癌抗原水平与食管鳞状细胞癌的淋巴结转移有关，特别是在T早期的患者。术前血清CYFRA21-1水平是淋巴结转移的独立预测因子。