Calcium-activated chloride channels (CaCCs) are widely expressed in various tissues and implicated in physiological processes such as sensory transduction, epithelial secretion, and smooth muscle contraction. Transmembrane proteins with unknown function 16 (TMEM16A) has recently been identified as a major component of CaCCs. Detailed molecular analysis of TMEM16A will be needed to understand its structure-function relationships. The role this channel plays in physiological systems remains to be established and is currently a subject of intense investigation.

中文翻译：

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国际基础和临床药理学联合会。LXXXV：钙激活的氯离子通道。

钙激活氯离子通道 (CaCCs) 在各种组织中广泛表达，并参与生理过程，如感觉转导、上皮分泌和平滑肌收缩。具有未知功能的跨膜蛋白 16 (TMEM16A) 最近被确定为 CaCC 的主要成分。需要对 TMEM16A 进行详细的分子分析以了解其结构-功能关系。该通道在生理系统中的作用仍有待确定，目前是深入研究的主题。