Background: The governmental program of Brazilian Unified National Health System has already published studies on the incidence of inflammatory bowel diseases (IBD), but up until now, there have been no epidemiological studies in private centers in Brazil. However, these diseases tend to affect people from a higher socioeconomic class, mainly in the capital of MS state that has the third highest GDP in Brazil.
Objectives: The aim was to analyze an observational, descriptive study of an IBD database in a private center including: the side, behavior of the disease and medical management, the association of extra-intestinal manifestations, and the main clinical symptoms which led to the investigation and diagnosis of IBD.
Patients and methods: A cohort study was developed in which data of all patients with IBD were analyzed with SPSS software in a constructed electronic database.
Results: Of 329 patients, 212 (64.4%) had Crohn’s disease (CD) and 117 (35.6%) had ulcerative colitis (UC). Average age at diagnosis of CD was 36.19 (±14.33) and of UC was 41.61 (±15.37). An amount of 50.05% of the patients with CD and 72.7% (P<0.001) with UC were female. We have observed that concerning the first symptoms, diahrrea and blood feces corresponded to 70% in UC while in CD 50% of the patients presented diahrrea with blood feces, loss of weight corresponded to 50% and only diahrrea 25%. (P<0.001). Anti-TNFs corresponded to 56.2% being more frequent in CD 0.001%. CD patients used biologic therapy and antibiotics more frequently than those with UC. In conclusion, IBD is also frequent in private health care centers in Brazil; women are most affected. Symptoms such as diarrhea and bleeding, as well as diarrhea and weight loss, must be taken as warning signs to investigate for inflammatory disease. The use of biologic therapies is frequent in referral centers when patients have severe disease.

Keywords: Crohn’s disease, ulcerative Colitis, alert symptoms, behavior, anti-TNF, extra-intestinal manifestations



中文翻译：

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炎症性肠病：诊断时间、环境因素、临床过程和管理 - 在私人炎症性肠病中心进行的一项后续研究（2003-2017 年）。

背景：巴西统一国家卫生系统的政府项目已经发表了关于炎症性肠病（IBD）发病率的研究，但到目前为止，巴西的私人中心还没有流行病学研究。然而，这些疾病往往会影响社会经济阶层较高的人，主要是在巴西国内生产总值第三高的 MS 州首府。
目的：目的是分析对私人中心 IBD 数据库的观察性描述性研究，包括：疾病的侧面、行为和医疗管理、肠外表现的关联以及导致 IBD 的主要临床症状。 IBD的调查和诊断。
患者和方法：开展了一项队列研究，其中所有 IBD 患者的数据在构建的电子数据库中使用 SPSS 软件进行分析。
结果：在 329 名患者中，212 名（64.4%）患有克罗恩病（CD），117 名（35.6%）患有溃疡性结肠炎（UC）。诊断 CD 的平均年龄为 36.19 (±14.33)，诊断为 UC 的平均年龄为 41.61 (±15.37)。50.05% 的 CD 患者和 72.7% ( P <0.001) 的 UC 患者为女性。我们观察到，关于首发症状，UC 中 70% 的患者出现腹泻和血便，而 CD 中 50% 的患者出现腹泻伴血便，体重减轻 50%，只有 25%。(磷<0.001)。抗 TNF 对应于 56.2%，在 CD 0.001% 中更常见。CD 患者比 UC 患者更频繁地使用生物治疗和抗生素。总之，IBD 在巴西的私人医疗保健中心也很常见；妇女受影响最大。必须将腹泻和出血等症状以及腹泻和体重减轻作为检查炎症性疾病的警告信号。当患者患有严重疾病时，转诊中心经常使用生物疗法。

关键词：克罗恩病，溃疡性结肠炎，警觉症状，行为，抗肿瘤坏死因子，肠外表现