ABSTRACT Oxygenated (HBO) and deoxygenated hemoglobin (HBR) levels in the prefrontal cortex (PFC) were measured using functional near-infrared spectroscopy (fNIRS) to determine if PFC activity during a cognitive inhibition task distinguishes children with prenatal alcohol exposure (PAE, n = 26) from both typically developing controls (n = 19) and a contrast group of children with other neurobehavioral problems (n = 14). Despite showing evidence of increased PFC activity in the non-inhibitory condition relative to controls, children in the PAE group displayed reduced PFC HBO and increased HBR relative to both other groups in the inhibitory condition, suggesting reduced PFC activity but increased oxygen consumption without sufficient oxygen replacement.

中文翻译：

---

使用功能性近红外光谱来区分酒精相关的神经发育障碍

摘要：使用功能性近红外光谱 (fNIRS) 测量前额皮质 (PFC) 中的氧合 (HBO) 和脱氧血红蛋白 (HBR) 水平，以确定认知抑制任务期间 PFC 的活动是否能够区分产前酒精暴露的儿童（PAE，n = 26）来自正常发育的对照组（n = 19）和患有其他神经行为问题的对照组儿童（n = 14）。尽管有证据表明非抑制条件下的 PFC 活性相对于对照组有所增加，但与抑制条件下的其他两组相比，PAE 组的儿童表现出 PFC HBO 降低和 HBR 增加，这表明 PFC 活性降低，但在没有足够氧气的情况下耗氧量增加替代品。