Fibropapillomatosis of sea turtles is traditionally treated with surgical debulking techniques that are often associated with prolonged healing and tumor recurrence. Electrochemotherapy was recently described for green turtles Chelonia mydas and can be an alternative to surgery and even general anesthesia. The objectives of this study were to replicate an electrochemotherapy protocol from a previous report and add plasma bleomycin analysis to the treatment. After bleomycin injection into similarly sized tumors of two green turtles and immediate electroporation at two time points, plasma bleomycin reached detectable concentrations that were considerably lower than those found in human studies. At 3 months posttherapy, no healing complications or recurrences were encountered and only scar tissue remained. This study adds further support that electrochemotherapy with bleomycin has the potential to be used as an effective alternative treatment for this complex disease.

中文翻译：

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绿海龟纤维乳头状瘤电化学治疗期间的血浆博莱霉素浓度

海龟的纤维乳头状瘤病传统上采用手术减瘤技术治疗，这些技术通常与愈合时间延长和肿瘤复发有关。最近描述了针对绿海龟 Chelonia mydas 的电化学疗法，可以替代手术甚至全身麻醉。本研究的目的是复制先前报告中的电化学治疗方案，并将血浆博来霉素分析添加到治疗中。在将博来霉素注射到两只绿海龟的类似大小的肿瘤中并在两个时间点立即进行电穿孔后，血浆博来霉素达到可检测的浓度，远低于人类研究中发现的浓度。治疗后 3 个月，没有出现愈合并发症或复发，仅留下疤痕组织。