Background: Developing a controllable drug delivery system is imperative and important to reduce side effects and enhance the therapeutic efficacy of drugs. Metal-organic frameworks (MOFs) an emerging class of hybrid porous materials built from metal ions or clusters bridged by organic linkers have attracted increasing attention in the recent years owing to the unique physical structures possessed, and the potential for vast applications. The superior properties of MOFs, such as well-defined pore aperture, tailorable composition and structure, tunable size, versatile functionality, high agent loading, and improved biocompatibility, have made them promising candidates as drug delivery hosts. MOFs for drug delivery is of great interest and many very promising results have been found, indicating that these porous solids exhibit several advantages over existing systems.

Objective: This review highlights the latest advances in the synthesis, functionalization, and applications of MOFs in drug delivery, and has classified them using drug loading strategies. Finally, challenges and future perspectives in this research area are also outlined.

背景：开发可控的药物输送系统对于减少副作用和提高药物的治疗效果至关重要。金属有机骨架（MOF）是一类新兴的由有机离子桥接的金属离子或簇构成的杂化多孔材料，由于其独特的物理结构及其潜在的广泛应用，近年来受到越来越多的关注。MOF的卓越性能，例如定义明确的孔径，可调整的组成和结构，可调节的尺寸，多功能的功能，高的载药量以及改善的生物相容性，使其成为有希望成为药物输送宿主的候选药物。用于药物输送的MOF引起了人们的极大兴趣，并且已经发现了许多非常有希望的结果，

目的：本综述重点介绍了MOF在药物递送中的合成，功能化和应用方面的最新进展，并使用载药策略对其进行了分类。最后，还概述了该研究领域中的挑战和未来前景。