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Natural Products as Potential anti-Alzheimer Agents.
Current Medicinal Chemistry ( IF 3.5 ) Pub Date : 2020-09-30 , DOI: 10.2174/0929867326666190618113613
Siva S Panda 1 , Nancy Jhanji 1
Affiliation  

Medicinal plants have curative properties due to the presence of various complex chemical substances of different composition, which are found as secondary metabolites in one or more parts of the plant. The diverse secondary metabolites play an important role in the prevention and cure of various diseases including neurodegenerative diseases like Alzheimer’s disease. Naturally occurring compounds such as flavonoids, polyphenols, alkaloids, and glycosides found in various parts of the plant and/or marine sources may potentially protect neurodegeneration as well as improve memory and cognitive function. Many natural compounds show anti-Alzheimer activity through specific pharmacological mechanisms like targeting β-amyloid, Beta-secretase 1 and Acetylcholinesterase. In this review, we have compiled more than 130 natural products with a broad diversity in the class of compounds, which were isolated from different sources showing anti- Alzheimer properties.



中文翻译:

天然产物作为潜在的抗阿尔茨海默病制剂。

药用植物由于存在不同成分的各种复杂化学物质而具有治疗作用,这些化学物质在植物的一个或多个部位被发现为次生代谢产物。多种次生代谢产物在预防和治疗包括神经退行性疾病(如阿尔茨海默氏病)在内的各种疾病中起着重要作用。在植物和/或海洋来源的各个部分中发现的天然存在的化合物,例如类黄酮,多酚,生物碱和糖苷,可能潜在地保护神经变性并改善记忆和认知功能。许多天然化合物通过特定的药理机制(例如靶向β-淀粉样蛋白,β-分泌酶1和乙酰胆碱酯酶)显示出抗阿尔茨海默氏病活性。在这篇评论中

更新日期:2020-10-30
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