Ailments of the bladder are often treated via intravesical delivery-direct application of therapeutic into the bladder through a catheter. This technique is employed hundreds of thousands of times every year, but protocol development has largely been limited to empirical determination. Furthermore, the numerical analyses of intravesical delivery performed to date have been restricted to static geometries and have not accounted for bladder deformation. This study uses a finite element analysis approach with biphasic solute transport to investigate several parameters pertinent to intravesical delivery including solute concentration, solute transport properties and instillation volume. The volume of instillation was found to have a substantial impact on the exposure of solute to the deeper muscle layers of the bladder, which are typically more difficult to reach. Indeed, increasing the instillation volume from 50-100 ml raised the muscle solute exposure as a percentage of overall bladder exposure from 60-70% with higher levels achieved for larger instillation volumes. Similar increases were not seen for changes in solute concentration or solute transport properties. These results indicate the role that instillation volume may play in targeting particular layers of the bladder during an intravesical delivery.

中文翻译：

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使用可变形几何结构中的双相溶质转运分析滴注量对膀胱内递送的影响。

膀胱疾病通常通过膀胱内膀胱内治疗直接通过导管将治疗剂应用到膀胱中进行治疗。这项技术每年被使用数十万次，但是协议开发在很大程度上仅限于经验确定。此外，迄今为止进行的膀胱内输送的数值分析仅限于静态几何形状，并未考虑膀胱变形。这项研究使用有限元分析方法与双相溶质运输来调查与膀胱内输送有关的几个参数，包括溶质浓度，溶质运输性质和滴注量。发现滴注量对溶质暴露于膀胱深层肌肉层有很大影响，通常很难达到。的确，将滴注量从50-100 ml增加到肌肉溶质暴露占膀胱总暴露量的百分比从60-70％提高了较大滴注量时的水平。溶质浓度或溶质传输特性的变化未见类似的增加。这些结果表明，在膀胱内输送过程中，滴注量可能在靶向膀胱的特定层中发挥作用。