Articular cartilage is an important load-bearing tissue distributed on the surface of diarthrodial joints. Due to its avascular, aneural and non-lymphatic features, cartilage has limited self-regenerative properties. To date, the utilization of biomaterials to aid in cartilage regeneration, especially through the use of injectable scaffolds, has attracted considerable attention. Various materials, therapeutics and fabrication approaches have emerged with a focus on manipulating the cartilage microenvironment to induce the formation of cartilaginous structures that have similar properties to the native tissues. In particular, the design and fabrication of injectable hydrogel-based scaffolds have advanced in recent years with the aim of enhancing its therapeutic efficacy and improving its ease of administration. This review summarizes recent progress in these efforts, including the structural improvement of scaffolds, network cross-linking techniques and strategies for controlled release, which present new opportunities for the development of injectable scaffolds for cartilage regeneration.

中文翻译：

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用于软骨再生的可注射水凝胶基支架的研究进展。

关节软骨是分布在双关节关节表面的重要承重组织。由于其无血管，非神经和非淋巴的特征，软骨具有有限的自我再生特性。迄今为止，尤其是通过使用可注射支架，利用生物材料来辅助软骨再生已引起相当大的关注。已经出现了各种材料，治疗方法和制造方法，其重点是操纵软骨微环境以诱导具有与天然组织相似性质的软骨结构的形成。特别地，近年来可注射的基于水凝胶的支架的设计和制造已经发展，其目的是增强其治疗功效并改善其给药的容易性。