The Discoidin Domain Receptor 1 (DDR1) receptor tyrosine kinase performs pleiotropic functions in the control of cell adhesion, proliferation, survival, migration, and invasion. Aberrant DDR1 function as a consequence of either mutations or increased expression has been associated with various human diseases including cancer. Pharmacological inhibition of DDR1 results in significant therapeutic benefit in several pre-clinical cancer models. Here, we discuss the potential implication of DDR1-dependent pro-survival functions in the development of cancer resistance to chemotherapeutic regimens and speculate on the molecular mechanisms that might mediate such important feature.

中文翻译：

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Discoidin域受体1在癌症化学抗性中的假定作用。

Discoidin域受体1（DDR1）酪氨酸激酶在控制细胞粘附，增殖，存活，迁移和侵袭中发挥多效功能。突变或表达增加导致的异常DDR1功能与包括癌症在内的多种人类疾病有关。DDR1的药理抑制作用可在几种临床前癌症模型中产生显着的治疗益处。在这里，我们讨论了DDR1依赖的生存功能在癌症对化疗方案耐药性发展中的潜在影响，并推测了可能介导这种重要特征的分子机制。