We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 262 Mexicans from the state of Guanajuato living in the cities of Guanajuato (N = 78), León (N = 22) and rural communities (N = 162), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes found in the state of Guanajuato include 12 Native American and three European haplotypes. Admixture estimates revealed that the main genetic components in the state of Guanajuato are Native American (50.64 ± 2.11% by ML, 43.35% of Native American haplotypes) and European (44.14 ± 1.14% by ML; 39.35% of European haplotypes), while African genetic component is less apparent (5.22 ± 2.08% by ML; 8.36% of African haplotypes).

我们研究了HLA I类（HLA-A，-B）和II类（HLA-DRB1，-DQB1）基于PCR-SSP的等位基因在来自瓜纳华托州（N = 78），莱昂（N = 22）和农村社区（N = 162）城市的瓜纳华托州的262名墨西哥人中进行分类，以获得有关等位基因和单倍型的信息频率。我们发现在瓜纳华托州发现的最常见单倍型包括12个美洲原住民和3个欧洲单倍型。混合物估计显示，瓜纳华托州的主要遗传成分是美洲原住民（按ML分类为50.64±2.11％，美国原住民单倍型为43.35％）和欧洲（按ML分类为44.14±1.14％；欧洲单倍型为39.35％），而非洲人遗传成分不太明显（按ML方法，为5.22±2.08％；非洲单倍型的8.36％）。