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Influence of moderate beer consumption on human gut microbiota and its impact on fasting glucose and β-cell function.
Alcohol ( IF 2.5 ) Pub Date : 2019-06-12 , DOI: 10.1016/j.alcohol.2019.05.006 Fernando Hernández-Quiroz 1 , Khemlal Nirmalkar 1 , Loan Edel Villalobos-Flores 1 , Selvasankar Murugesan 1 , Yair Cruz-Narváez 2 , Enrique Rico-Arzate 2 , Carlos Hoyo-Vadillo 3 , Alejandra Chavez-Carbajal 1 , María Luisa Pizano-Zárate 4 , Jaime García-Mena 1
Alcohol ( IF 2.5 ) Pub Date : 2019-06-12 , DOI: 10.1016/j.alcohol.2019.05.006 Fernando Hernández-Quiroz 1 , Khemlal Nirmalkar 1 , Loan Edel Villalobos-Flores 1 , Selvasankar Murugesan 1 , Yair Cruz-Narváez 2 , Enrique Rico-Arzate 2 , Carlos Hoyo-Vadillo 3 , Alejandra Chavez-Carbajal 1 , María Luisa Pizano-Zárate 4 , Jaime García-Mena 1
Affiliation
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Beer is a beverage that has been consumed worldwide for thousands of years due to social, religious, and cultural reasons; it contains polyphenolic compounds as well as phenolic acids with a potential positive effect on human health. This study aimed to explore the impact of moderate beer consumption on human health and gut microbiota diversity. Three hundred fifty-five mL of non-alcoholic beer (NAB) or alcoholic beer (AB) were consumed daily by the participants for 30 days in each study. Anthropometric measures, blood samples for biochemistry, and fecal samples for microbiota analysis were collected on Day 1 and Day 30. Microbial diversity was characterized by high-throughput sequencing of 16S rDNA libraries, and data were analyzed using the QIIME pipeline. We found that NAB and AB have effects on the composition of the gut microbiota, favoring the proliferation of Bacteroidetes with respect to Firmicutes. No increase in weight, waist, and hip parameters was observed, and the liver and lipid profile values were not modified for NAB. In addition, the consumption of NAB induced a decrease in fasting blood serum glucose and an increase in functional β cells, while, on the other hand, there was an increase in blood serum glucose and a decrease in functional β cells with the consumption of AB. In general, beer consumption neither changed anthropometric values, nor affected liver function. Although the glucose values decreased with NAB or increased with AB, they remained within the normal range. Our conclusion is that moderate consumption of NAB has a positive effect on human health via supplementation of biological active polyphenol and phenolic acids, and by enrichment of the gut microbiota diversity with beneficial bacteria, while the presence of alcohol in AB interferes with this effect. More work should be done on this topic before general conclusions are drawn.
中文翻译：
适度饮啤酒对人肠道菌群的影响及其对空腹血糖和β细胞功能的影响。
啤酒是一种由于社会，宗教和文化原因已在世界范围内消费了数千年的饮料。它包含多酚类化合物和酚酸，对人类健康有潜在的积极影响。这项研究旨在探讨适度饮用啤酒对人类健康和肠道菌群多样性的影响。在每个研究中，参与者每天消耗三百五十五毫升的非酒精啤酒（NAB）或酒精啤酒（AB）。在第1天和第30天收集人体测量指标，用于生物化学的血液样本和用于微生物群分析的粪便样本。通过16S rDNA文库的高通量测序来表征微生物多样性，并使用QIIME管道分析数据。我们发现NAB和AB对肠道菌群的组成有影响，有利于拟杆菌科细菌的繁殖。没有观察到体重，腰部和臀部参数的增加，并且NAB的肝脏和脂质谱值未改变。另外，NAB的消耗引起空腹血糖降低，功能性β细胞增加，而另一方面，AB的消耗引起血清葡萄糖升高，功能性β细胞减少。 。通常，饮用啤酒既不会改变人体测量值，也不会影响肝功能。尽管葡萄糖值随NAB降低或随AB升高，但仍保持在正常范围内。我们的结论是，适量摄入NAB可以通过补充生物活性多酚和酚酸对人类健康产生积极影响，并通过有益细菌丰富肠道菌群多样性，而AB中酒精的存在会干扰这种作用。在得出一般性结论之前，应在该主题上做更多的工作。
更新日期：2020-04-20
中文翻译：
适度饮啤酒对人肠道菌群的影响及其对空腹血糖和β细胞功能的影响。
啤酒是一种由于社会，宗教和文化原因已在世界范围内消费了数千年的饮料。它包含多酚类化合物和酚酸，对人类健康有潜在的积极影响。这项研究旨在探讨适度饮用啤酒对人类健康和肠道菌群多样性的影响。在每个研究中，参与者每天消耗三百五十五毫升的非酒精啤酒（NAB）或酒精啤酒（AB）。在第1天和第30天收集人体测量指标，用于生物化学的血液样本和用于微生物群分析的粪便样本。通过16S rDNA文库的高通量测序来表征微生物多样性，并使用QIIME管道分析数据。我们发现NAB和AB对肠道菌群的组成有影响，有利于拟杆菌科细菌的繁殖。没有观察到体重，腰部和臀部参数的增加，并且NAB的肝脏和脂质谱值未改变。另外，NAB的消耗引起空腹血糖降低，功能性β细胞增加，而另一方面，AB的消耗引起血清葡萄糖升高，功能性β细胞减少。 。通常，饮用啤酒既不会改变人体测量值，也不会影响肝功能。尽管葡萄糖值随NAB降低或随AB升高，但仍保持在正常范围内。我们的结论是，适量摄入NAB可以通过补充生物活性多酚和酚酸对人类健康产生积极影响，并通过有益细菌丰富肠道菌群多样性，而AB中酒精的存在会干扰这种作用。在得出一般性结论之前，应在该主题上做更多的工作。
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