The risk of transfusion-associated sepsis due to transmission of bacteria is a persistent problem in the transfusion field. Despite numerous interventions to reduce the risk, cases of bacterial sepsis following transfusion are repeatedly being reported. Especially platelet concentrates are highly susceptible to bacterial contaminations due to the growth-promoting storage conditions. In Europe, blood establishments and national authorities have implemented individual precaution measures to mitigate the risk of bacterial transmission. To obtain an overview of the different approaches, we compiled information from national authorities, blood establishments, and the current literature. Several aspects such as the shelf life of platelets, time of sampling and the applied control measures are compared between the member states. The analysis of the data revealed a broad heterogeneity of procedures on a national level ranging from platelet release without any safety testing up to mandatory screening of all platelet concentrates prior to transfusion. Despite the substantial progress made in recent years, several bacterial reports on transfusion-associated sepsis indicate that further efforts are needed to increase the safety of blood transfusions in the long term.

中文翻译：

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欧洲浓缩血小板的微生物筛查


由于细菌传播而导致输血相关败血症的风险是输血领域持续存在的问题。尽管采取了许多干预措施来降低风险，但输血后细菌性败血症的病例仍不断被报道。由于促进生长的储存条件，浓缩血小板尤其容易受到细菌污染。在欧洲，血液机构和国家当局已实施个人预防措施，以降低细菌传播的风险。为了获得不同方法的概述，我们收集了来自国家当局、血液机构和当前文献的信息。对成员国之间的血小板保质期、采样时间和所采用的控制措施等几个方面进行了比较。数据分析揭示了国家层面的程序存在广泛的异质性，从没有任何安全测试的血小板释放到输血前对所有血小板浓缩物的强制筛查。尽管近年来取得了实质性进展，但一些关于输血相关脓毒症的细菌报告表明，从长远来看，需要进一步努力提高输血的安全性。