Neuroinflammation is a typical feature of many neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. Microglia, the resident immune cells of the brain, readily become activated in response to an infection or an injury. Uncontrolled and overactivated microglia can release pro-inflammatory and cytotoxic factors and are the major culprits in neuroinflammation. Hence, research on novel neuroinflammatory inhibitors is of paramount importance for the treatment of neurodegenerative diseases. Bacterial lipopolysaccharide, widely used in the studies of brain inflammation, initiates several major cellular activities that critically contribute to the pathogenesis of neuroinflammation. This review will highlight the progress on terpenoids, an important and structurally diverse group of natural compounds, as neuroinflammatory inhibitors in lipopolysaccharidestimulated BV-2 microglial cells over the last 20 years.

神经炎症是许多神经退行性疾病的典型特征，包括阿尔茨海默氏病和帕金森氏病。小胶质细胞是大脑的常驻免疫细胞，在感染或受伤后很容易被激活。不受控制和过度激活的小胶质细胞可以释放促炎和细胞毒性因子，是神经炎症的主要元凶。因此，对新型神经炎性抑制剂的研究对于神经退行性疾病的治疗至关重要。细菌脂多糖广泛用于脑部炎症的研究，它启动了几种主要的细胞活动，这些活动对神经炎症的发病机理至关重要。这篇评论将重点介绍萜烯类化合物的进展，萜烯类化合物是结构上重要且结构多样的一组，