Immunological aging, which encompasses age-associated declines in the immune system (immunosenescence) and increases in inflammation (inflammaging), is associated with morbidity and mortality. A growing body of research suggests stress is one factor that may accelerate immunological aging. This article provides a brief overview of immunological aging, describes key biological pathways acting at multiple lifespan stages linking stress and immunological aging, and reviews recent innovative work characterizing associations between stress in several domains and immunological aging, as well as potential protective and risk factors. Important directions for future research include careful characterizations of the complexities of stress and rigorous measurement of immunological aging processes. Advancing knowledge of stress resilience and healthy immune aging may ultimately slow disease onset and extend healthspan.

免疫衰老与发病率和死亡率有关，其中包括与年龄相关的免疫系统下降（免疫衰老）和炎症增加（发炎）。越来越多的研究表明，压力是可能加速免疫老化的因素之一。本文简要概述了免疫学衰老，描述了在多个生命周期阶段将压力与免疫学衰老联系起来的关键生物学途径，并回顾了表征在多个领域的压力与免疫学衰老之间的关联以及潜在的保护性和危险因素的最新创新工作。未来研究的重要方向包括对压力复杂性的仔细表征以及对免疫衰老过程的严格测量。