Abstract

We aimed at reporting the chemical constituents and antimicrobial activities of Leea aequata L., a traditional folk medicine used in Myanmar for the treatment of wounds and skin diseases. A new neolignan, (7S,8R)-9′-O-acetylcedrusin (1), a new lactam, (3S,4S)-4-chloro-3-hydroxypiperidin-2-one (2), along with 21 known compounds, including five lignans (3–7), four flavonoid glycosides (8–11), and others (12–23), were isolated from the ethanoic extract of the aerial parts of L. aequata. The structures of the new compounds were determined by NMR, MS, and ECD spectra. For all the antimicrobial tests of the 23 compounds, only 3,4,5-trihydroxybenzoic acid ethyl ester (17) showed weak inhibitory activities against Escherichia coli and Salmonella enterica subsp. enterica.

Graphical Abstract

中文翻译：

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缅甸传统民药“利阿”（Lea aequata L.）地上部分的乙醇提取物的化学成分。

摘要

我们的目标是报告Leea aequata L.的化学成分和抗菌活性，Leea aequata L.是缅甸用于治疗伤口和皮肤疾病的传统民间药物。一个新的新木脂素，（7 S，8 R）-9'- O-乙酰乙酰木素（1），一个新的内酰胺，（3 S，4 S）-4-氯-3-羟基哌啶-2-酮（2）， 21个已知的化合物，包括五个木脂素（3 - 7），四节黄酮苷（8 - 11），和其他（12 - 23），从地上部分的林克芝提取物中分离L. aequata。新化合物的结构通过NMR，MS和ECD光谱确定。对于这23种化合物的所有抗菌测试，只有3,4,5-三羟基苯甲酸乙酯（17）对大肠杆菌和肠炎沙门氏菌亚种的抑制活性较弱。肠衣。

图形概要