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A meta-analysis of epidemiologic studies of occupationally exposed styrene workers and micronuclei levels.
Mutation Research/Genetic Toxicology and Environmental Mutagenesis ( IF 2.3 ) Pub Date : 2019-01-01 , DOI: 10.1016/j.mrgentox.2018.08.011
James J Collins 1 , Martha Moore 2
Affiliation  

Previous reviews and meta-analyses have reached different conclusions on whether high styrene exposure increase micronucleus frequencies. The most recent meta-analysis reports an increase in these frequencies related to styrene. We update this meta-analysis of micronucleus frequencies with additional studies not previously included, eliminate double counting of study subjects appearing in more than one publication, considered levels of styrene exposures in the analysis, assess publication bias, and examine consistency of findings across studies. Our meta-analysis used the standardized mean difference as the summary statistic since all studies assess the same outcome but use different comparison populations. The primary meta-analysis of the 12 studies of 516 styrene exposed workers and 497 non-exposed comparisons produces a meta-mean difference of 1.19 (95% CI 0. 20-2.18, random effects model), but there was substantial heterogeneity across studies (I2 of 97.47, p-value <0.001, fixed effect model). We also observed that studies with higher styrene exposure had a higher mean standard difference compared with studies with lower styrene exposures. However, a longitudinal study did not find any association with styrene exposure and micronucleus frequencies. Given the lack of consistency across studies and the equivocal finding on exposure response, these data are insufficient to support a conclusion that an increase in micronucleus frequencies is due to styrene exposure.

中文翻译:

对职业暴露的苯乙烯工人和微核水平进行的流行病学研究的荟萃分析。

先前的评论和荟萃分析对高苯乙烯暴露是否会增加微核频率得出了不同的结论。最新的荟萃分析报告这些与苯乙烯相关的频率增加。我们使用以前未包括的其他研究更新了对微核频率的荟萃分析,消除了对不只一份出版物中出现的研究对象的重复计数,在分析中考虑了苯乙烯暴露的水平,评估了出版物的偏倚,并检查了研究结果的一致性。我们的荟萃分析使用标准化的均值差作为汇总统计量,因为所有研究均评估相同的结果,但使用不同的比较人群。对516名暴露于苯乙烯的工人的12项研究和497次未暴露的比较的主要荟萃分析得出的均值差异为1.19(95%CI 0. 20-2.18,随机效应模型),但各研究之间存在很大的异质性(I2为97.47,p值<0.001,固定效应模型)。我们还观察到,与较低苯乙烯暴露的研究相比,较高苯乙烯暴露的研究具有较高的平均标准差。然而,一项纵向研究未发现与苯乙烯暴露和微核频率有任何关联。鉴于各研究之间缺乏一致性以及对暴露反应的模棱两可的发现,这些数据不足以支持微核频率增加归因于苯乙烯暴露的结论。但研究之间存在很大的异质性(I2为97.47,p值<0.001,固定效应模型)。我们还观察到,与较低苯乙烯暴露的研究相比,较高苯乙烯暴露的研究具有较高的平均标准差。然而,一项纵向研究未发现与苯乙烯暴露和微核频率有任何关联。鉴于各研究之间缺乏一致性以及对暴露反应的模棱两可的发现,这些数据不足以支持微核频率增加归因于苯乙烯暴露的结论。但研究之间存在很大的异质性(I2为97.47,p值<0.001,固定效应模型)。我们还观察到,与较低苯乙烯暴露的研究相比,较高苯乙烯暴露的研究具有较高的平均标准差。然而,一项纵向研究未发现与苯乙烯暴露和微核频率有任何关联。鉴于各研究之间缺乏一致性以及对暴露反应的模棱两可的发现,这些数据不足以支持微核频率增加归因于苯乙烯暴露的结论。一项纵向研究未发现与苯乙烯暴露和微核频率有关。鉴于各研究之间缺乏一致性以及对暴露反应的模棱两可的发现,这些数据不足以支持微核频率增加归因于苯乙烯暴露的结论。一项纵向研究未发现与苯乙烯暴露和微核频率有任何关联。鉴于各研究之间缺乏一致性以及对暴露反应的模棱两可的发现,这些数据不足以支持微核频率增加归因于苯乙烯暴露的结论。
更新日期:2019-11-01
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