This review focuses on recent evidences about human microbiome composition and functions, exploring the potential implication of its impairment in some diffuse and invalidating inflammatory skin diseases, such as atopic dermatitis, psoriasis, hidradenitis suppurativa and acne. We analysed current scientific literature, focusing on the current evidences about gut and skin microbiome composition and the complex dialogue between microbes and the host. Finally, we examined the consequences of this dialogue for health and skin diseases. This review highlights how human microbes interact with different anatomic niches modifying the state of immune activation, skin barrier status, microbe-host and microbe-microbe interactions. It also shows as most of the factors affecting gut and skin microorganisms' activity have demonstrated to be effective also in modulating chronic inflammatory skin diseases. More and more evidences demonstrate that human microbiome plays a key role in human health and diseases. It is to be expected that these new insights will translate into diagnostic, therapeutic and preventive measures in the context of personalized/precision medicine.

中文翻译：

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人类微生物组：在炎症性皮肤病中的组成和作用。

这篇综述集中在有关人类微生物组组成和功能的最新证据上，探讨了其在某些弥散性和无效性炎症性皮肤病（如特应性皮炎，牛皮癣，化脓性汗腺炎和痤疮）中的潜在影响。我们分析了当前的科学文献，重点关注有关肠道和皮肤微生物组组成以及微生物与宿主之间复杂对话的最新证据。最后，我们研究了这种对话对健康和皮肤疾病的影响。这篇综述强调了人类微生物如何与不同的解剖位点相互作用，从而改变免疫激活状态，皮肤屏障状态，微生物宿主和微生物-微生物相互作用。它也显示出影响肠道和皮肤微生物的大多数因素。活性已被证明在调节慢性炎症性皮肤病中也是有效的。越来越多的证据表明，人类微生物组在人类健康和疾病中起着关键作用。可以预期，这些新见解将在个性化/精密医学的背景下转化为诊断，治疗和预防措施。