The Hippo signaling pathway regulates organ size and tissue homeostasis. Given this role it is unsurprising that dysregulation of this pathway has implications for cancer progression. A convincing body of literature shows that the Hippo pathway serves a tumor suppressive function with its inactivation leading to massive overgrowth. However, additional studies have also shown that activation of Hippo signaling can promote tumor progression. It remains unknown how a single pathway can produce such diametrically opposed effects. This lack of knowledge is in part due to our inability to make meaningful comparisons from studies which have taken place in a variety of cell types, tissues, and organisms. Recently however, we have published 2 studies using the Drosophila wing disk to study the Hippo pathway and have found that Hippo pathway activation can promote cell migration and invasion while Hippo pathway inactivation leads to overgrowth. Thus we propose here that Drosophila can provide a research platform with which to begin addressing how the Hippo pathway can both enhance and suppress tumor progression due to published pro- and anti-tumor functionalities of the Hippo pathway in the same tissue.

河马信号通路调节器官的大小和组织稳态。鉴于此作用，该途径的异常调节对癌症的进展有影响，这一点不足为奇。有说服力的文献表明，Hippo途径具有失活导致大量过度生长的肿瘤抑制功能。但是，其他研究也表明，激活Hippo信号可以促进肿瘤进展。单个途径如何产生这种截然相反的效果仍是未知的。缺乏知识的部分原因是我们无法对已经在各种细胞类型，组织和生物体中进行的研究进行有意义的比较。然而，最近我们发表了2项使用果蝇的研究翼盘研究Hippo途径，并发现Hippo途径激活可促进细胞迁移和侵袭，而Hippo途径失活则导致过度生长。因此，我们在此提出果蝇可以提供一个研究平台，通过该平台开始研究由于在同一组织中已发布的Hippo通路的抗肿瘤和抗肿瘤功能，Hippo通路如何既可以增强又可以抑制肿瘤进展。