The filovirus family includes some of the deadliest viruses known, including Ebola virus and Marburg virus. These viruses cause periodic outbreaks of severe disease that can be spread from person to person, making the filoviruses important public health threats. There remains a need for approved drugs that target all or most members of this virus family. Small molecule inhibitors that target conserved functions hold promise as pan-filovirus therapeutics. To date, compounds that effectively target virus entry, genome replication, gene expression, and virus egress have been described. The most advanced inhibitors are nucleoside analogs that target viral RNA synthesis reactions.

丝状病毒家族包括一些已知的最致命的病毒，包括埃博拉病毒和马尔堡病毒。这些病毒会引起严重疾病的周期性爆发，并可能在人与人之间传播，从而使线状病毒成为重要的公共卫生威胁。仍然需要针对该病毒家族所有或大多数成员的批准药物。靶向保守功能的小分子抑制剂有望作为泛丝状病毒治疗剂。迄今为止，已经描述了有效靶向病毒进入，基因组复制，基因表达和病毒流出的化合物。最先进的抑制剂是靶向病毒RNA合成反应的核苷类似物。