This paper explores clinicians’ and scientists’ accounts of genomic research in cancer care and the complexities and challenges involved with delivering this work. Contributing to the sociology of (low) expectations, we draw on sociological studies of uncertainty in medicine to explore their accounts of working with uncertainty as part of the management of patient and institutional expectations. We consider their appeals to the importance of modest inquiry and framing of the uncertainties of genomic medicine as normal and at times welcome as they sought to configure professional autonomy and jurisdictions and cultivate an experimental ethos amongst their patients. We argue that these types of uncertainty work [Star, S. L. 1985. “Scientific Work and Uncertainty.” Social Studies of Science 15 (3): 391–427] are a key feature of managing expectations at the intersections of genomic research and clinical care.

中文翻译：

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基因组研究和癌症临床：专业账户的不确定性和期望

本文探讨了临床医生和科学家对癌症护理中基因组研究的描述以及开展这项工作所涉及的复杂性和挑战。为了对（低）期望的社会学做出贡献，我们利用医学不确定性的社会学研究来探索他们对不确定性的描述，作为患者和机构期望管理的一部分。我们认为，他们对适度探究和构建基因组医学不确定性的重要性的呼吁是正常的，有时是值得欢迎的，因为他们试图配置专业自主权和管辖权，并在患者中培养实验精神。我们认为这些类型的不确定性是有效的 [Star, SL 1985.“科学工作与不确定性”。Social Studies of Science 15 (3): 391–427] 是在基因组研究和临床护理交叉点管理期望的一个关键特征。