Cannabidiol (CBD), the non-psychoactive component of Cannabis sativa, acts on a diverse selection of membrane proteins with promising therapeutic potential in epilepsy and chronic pain. One such protein is the voltage-gated sodium channel (Na_v). CBD shows a lack of specificity for sodium channels; however, the method of interaction is still unknown. In this review, we will outline the studies that report reproducible results of CBD and other cannabinoids changing membrane channel function, with particular interest on Na_v. Na_v are implicated in fatal forms of epilepsy and are also associated with chronic pain. This makes Na_v potential targets for CBD interaction since it has been reported to reduce pain and seizures. One potential method of interaction that is of interest in this review is whether CBD affects channel function by altering lipid bilayer properties, independent of any possible direct interaction with membrane channels. CBD’s ability to interact with its targets is a novel and important discovery. This discovery will not only prompt further research towards CBD’s characterization, but also promotes the application of cannabinoids as potentially therapeutic compounds for diseases like epilepsy and pain.

大麻脂（CBD）是大麻的非精神活性成分，它作用于多种膜蛋白，在癫痫和慢性疼痛中具有广阔的治疗潜力。一种这样的蛋白质是电压门控钠通道（Na _v）。CBD对钠通道缺乏特异性。但是，交互方法仍然未知。在这篇综述中，我们将概述报告CBD和其他大麻素改变膜通道功能的可再现结果的研究，尤其是对Na _v的关注。Na _v涉及致命形式的癫痫，也与慢性疼痛有关。这使Na _vCBD相互作用的潜在目标，因为据报道它可以减轻疼痛和癫痫发作。本文中关注的一种潜在的相互作用方法是CBD是否通过改变脂质双层特性来影响通道功能，而与膜通道的任何可能的直接相互作用无关。CBD与目标互动的能力是一项新颖而重要的发现。这一发现不仅将促进对CBD表征的进一步研究，而且还将促进大麻素作为癫痫和疼痛等疾病的潜在治疗化合物的应用。