A malignant brain tumor diagnosis is often accompanied by intense feelings and can be associated with psychosocial conditions including depression, anxiety, and increased distress levels. Previous work has highlighted the impact of uncontrolled psychological distress among brain tumor patients. Given the negative impact of maladaptive psychosocial and biobehavioral factors on normal immune system functions, the question remains as to how psychological conditions potentially affect the brain tumor patient anti-tumor immune response. Since immunotherapy has yet to show efficacy at increasing malignant glioma patient survival in all randomized, phase III clinical trials to-date, this review provides new insights into the potential negative effects of chronic distress on brain tumor patient immune functions and outcomes.

恶性脑肿瘤的诊断通常伴有强烈的感觉，并可能与心理社会状况有关，包括抑郁，焦虑和痛苦程度增加。先前的工作强调了脑肿瘤患者无法控制的心理困扰的影响。鉴于不良适应症的社会心理和生物行为因素对正常免疫系统功能的负面影响，关于心理状况如何潜在影响脑肿瘤患者抗肿瘤免疫反应的问题仍然存在。迄今为止，由于免疫疗法尚未显示出在增加所有恶性神经胶质瘤患者存活率方面的有效性，因此该综述为慢性困扰对脑肿瘤患者免疫功能和结果的潜在负面影响提供了新的见解。