Background: Dyslipidemia is a common disorder in systemic lupus erythematosus (SLE) patients. It is still inconclusive whether antimalarial drugs could affect the serum lipids in SLE patients, therefore we conducted a systematic review and meta-analysis of available data to address this issue. Methods: We comprehensively searched the databases of PubMed, EMBASE and Cochrane Library from date of inception to Sep 2018 for both randomized controlled trials (RCTs) and observational studies. Review Manager 5.3 software was used for analysis. We performed meta-analysis using random-effects model and weighted the mean difference (WMD) and its 95% confidence interval (CI). The Q test was used to assess the presence of heterogeneity and the I2 index was used to quantify the extent of heterogeneity. Results: In total, 8 studies met our selection criteria including 2 RCTs, 2 cohort studies, and 4 case-control studies. There were 717 patients (336 patients in CQ (chloroquine) or HCQ (hydroxychloroquine) group, and 381 patients in control group (SLE patients without the therapy of AM)). Compared with the control group, TC, TG, LDL-C, VLDL-C were associated with a significant decrease, respectively (WMD = −21.40 mg/dL, 95% CI −27.62 to −15.18, P < .00001), (WMD = −29.07 mg/dL, 95% CI −45.28 to −12.86, P = .0004), (WMD = −16.25 mg/dL, 95% CI −28.82 to −3.68, P = .01), (WMD = −6.41 mg/dL, 95% CI −12.39 to 0.44, P = .04), however the change of HDL-C did not reach statistically significance (WMD = 4.42 mg/dL, 95% CI −1.21 to 10.06, P = .12). Conclusions: CQ or HCQ can infect the serum lipids in SLE patients. However, these results should be interpreted with cautions since lacking sufficient RCTs.

中文翻译：

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抗疟药 (AM) 对系统性红斑狼疮 (SLE) 患者血脂的影响

背景：血脂异常是系统性红斑狼疮（SLE）患者的常见疾病。抗疟药是否会影响 SLE 患者的血脂尚无定论，因此我们对现有数据进行了系统回顾和荟萃分析以解决这一问题。方法：我们全面检索了 PubMed、EMBASE 和 Cochrane Library 从成立之日到 2018 年 9 月的数据库中的随机对照试验 (RCT) 和观察性研究。使用 Review Manager 5.3 软件进行分析。我们使用随机效应模型进行荟萃分析，并加权平均差 (WMD) 及其 95% 置信区间 (CI)。Q检验用于评估异质性的存在，I2指数用于量化异质性的程度。结果：总的来说，8 项研究符合我们的选择标准，包括 2 项 RCT、2 项队列研究和 4 项病例对照研究。717例患者（CQ（氯喹）或HCQ（羟氯喹）组336例，对照组381例（SLE患者未接受AM治疗））。与对照组相比，TC、TG、LDL-C、VLDL-C 分别与显着降低相关（WMD = -21.40 mg/dL，95% CI -27.62 至 -15.18，P < .00001），（ WMD = -29.07 mg/dL, 95% CI -45.28 至 -12.86, P = .0004), (WMD = -16.25 mg/dL, 95% CI -28.82 至 -3.68, P = .01), (WMD = -6.41 mg/dL，95% CI -12.39 至 0.44，P = .04），但 HDL-C 的变化未达到统计学意义（WMD = 4.42 mg/dL，95% CI -1.21 至 10.06，P = .12)。结论：CQ或HCQ可感染SLE患者的血脂。然而，