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A Miniature Configurable Wireless System for Recording Gastric Electrophysiological Activity and Delivering High-Energy Electrical Stimulation
IEEE Journal on Emerging and Selected Topics in Circuits and Systems ( IF 3.7 ) Pub Date : 2018-06-01 , DOI: 10.1109/jetcas.2018.2812105
Rui Wang 1 , Zaid Abukhalaf 1 , Amir Javan-Khoshkholgh 1 , Tim H-H Wang 2 , Shameer Sathar 3 , Peng Du 3 , Timothy R Angeli 3 , Leo K Cheng 3 , Greg O'Grady 3 , Niranchan Paskaranandavadivel 3 , Aydin Farajidavar 1
Affiliation  

The purpose of this paper is to develop and validate a miniature system that can wirelessly acquire gastric electrical activity called slow waves and deliver high-energy electrical pulses to modulate its activity. The system is composed of a front-end unit and an external stationary back-end unit that is connected to a computer. The front-end unit contains a recording module with three channels and a single-channel stimulation module. Commercial off-the-shelf components were used to develop front- and back-end units. A graphical user interface was designed in LabVIEW to process and display the recorded data in real-time and store the data for off-line analysis. The system was successfully validated on bench top and in vivo in porcine models. The bench-top studies showed an appropriate frequency response for analog conditioning and digitization resolution to acquire gastric slow waves. The system was able to deliver electrical pulses at amplitudes up to 10 mA to a load smaller than $880~\Omega $ . Simultaneous acquisition of the slow waves from all three channels was demonstrated in vivo. The system was able to modulate—by either suppressing or entraining—the slow wave activity. This paper reports the first high-energy stimulator that can be controlled wirelessly and integrated into a gastric bioelectrical activity monitoring system. The system can be used for treating functional gastrointestinal disorders.

中文翻译:

用于记录胃电生理活动和提供高能电刺激的微型可配置无线系统

本文的目的是开发和验证一种微型系统,该系统可以无线获取称为慢波的胃电活动,并提供高能电脉冲来调节其活动。该系统由一个前端单元和一个与计算机相连的外部固定后端单元组成。前端单元包含一个三通道记录模块和一个单通道刺激模块。商用现成组件用于开发前端和后端单元。在LabVIEW中设计了一个图形用户界面来实时处理和显示记录的数据并存储数据以供离线分析。该系统已在实验台和猪模型体内成功验证。台式研究显示了模拟调节和数字化分辨率的适当频率响应,以获取胃慢波。该系统能够以高达 10 mA 的幅度向小于 880 美元的负载传送电脉冲。在体内证明了从所有三个通道同时获取慢波。该系统能够通过抑制或夹带慢波活动来调节。本文报道了第一个可以无线控制并集成到胃生物电活动监测系统中的高能刺激器。该系统可用于治疗功能性胃肠疾病。在体内证明了从所有三个通道同时获取慢波。该系统能够通过抑制或夹带慢波活动来调节。本文报道了第一个可以无线控制并集成到胃生物电活动监测系统中的高能刺激器。该系统可用于治疗功能性胃肠疾病。在体内证明了从所有三个通道同时获取慢波。该系统能够通过抑制或夹带慢波活动来调节。本文报道了第一个可以无线控制并集成到胃生物电活动监测系统中的高能刺激器。该系统可用于治疗功能性胃肠疾病。
更新日期:2018-06-01
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