Cell migration is a highly orchestrated cellular event that involves physical interactions of diverse subcellular components. The nucleus as the largest and stiffest organelle in the cell not only maintains genetic functionality, but also actively changes its morphology and translocates through dynamic formation of nucleus-bound contractile stress fibers. Nuclear motion is an active and essential process for successful cell migration and nucleus self-repairs in response to compression and extension forces in complex cell microenvironment. This review recapitulates molecular regulators that are crucial for nuclear motility during cell migration and highlights recent advances in nuclear deformation-mediated rupture and repair processes in a migrating cell.

中文翻译：

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细胞迁移过程中核运动分子调节因子的概述。

细胞迁移是一种高度精心策划的细胞事件，涉及不同亚细胞成分的物理相互作用。细胞核作为细胞中最大、最硬的细胞器，不仅保持遗传功能，而且通过动态形成细胞核结合的收缩应力纤维，主动改变其形态并易位。核运动是细胞成功迁移和细胞核自我修复以响应复杂细胞微环境中的压缩和伸展力的活跃且重要的过程。这篇综述概述了细胞迁移过程中对核运动至关重要的分子调节因子，并强调了迁移细胞中核变形介导的破裂和修复过程的最新进展。