BACKGROUND: Antimicrobial resistance is a concern that is challenging the ability to treat common infections. Surveillance of antimicrobial use in pediatric acute care institutions is complicated because the common metric unit, the defined daily dose, is problematic for this population.OBJECTIVE: During a four-year period in which no specific antimicrobial stewardship initiatives were conducted, pediatric antimicrobial use was quantified using days of therapy (DOT) per 100 patient days (PD) (DOT/100 PD) at the Alberta Children’s Hospital (Calgary, Alberta) for benchmarking purposes.METHODS: Drug use data for systemic antimicrobials administered on wards at the Alberta Children’s Hospital were collected from electronic medication administration records. DOT were calculated and rates were determined using 100 PD as the denominator. Changes over the surveillance period and subgroup proportions were represented graphically and assessed using linear regression.RESULTS: Total antimicrobial use decreased from 93.6 DOT/100 PD to 75.7 DOT/100 PD (19.1%) over the 2010/2011 through to the 2013/2014 fiscal years. During this period, a 20.0% increase in PD and an essentially stable absolute count of DOT (2.9% decrease) were observed. Overall, antimicrobial use was highest in the pediatric intensive care and oncology units.DISCUSSION: The exact changes in prescribing patterns that led to the observed reduction in DOT/100 PD with associated increased PD are unclear, but may be a topic for future investigations.CONCLUSION: Antimicrobial use data from a Canadian acute care pediatric hospital reported in DOT/100 PD were compiled for a four-year time period. These data may be useful for benchmarking purposes.

中文翻译：

---

使用加拿大一家儿科急症护理医院的治疗天数测量四年期间的抗菌药物使用情况。


背景：抗生素耐药性是一个挑战治疗常见感染能力的问题。儿科急症护理机构抗菌药物使用情况的监测非常复杂，因为通用公制单位（定义的每日剂量）对该人群来说是有问题的。 目的：在没有实施具体抗菌药物管理举措的四年期间，儿科抗菌药物的使用情况使用阿尔伯塔儿童医院（阿尔伯塔省卡尔加里）每 100 个患者日 (PD) 的治疗天数 (DOT) (DOT/100 PD) 进行量化，以达到基准目的。方法：阿尔伯塔儿童医院病房内全身抗菌药物的药物使用数据医院从电子药物管理记录中收集。使用 100 PD 作为分母计算 DOT 并确定比率。监测期间和亚组比例的变化以图表形式表示，并使用线性回归进行评估。 结果：从 2010/2011 年到 2013/2014 年，抗菌药物使用总量从 93.6 DOT/100 PD 下降到 75.7 DOT/100 PD (19.1%)财政年度。在此期间，观察到 PD 增加了 20.0%，DOT 绝对计数基本稳定（减少 2.9%）。总体而言，儿科重症监护室和肿瘤科病房的抗菌药物使用量最高。讨论：导致观察到的 DOT/100 PD 减少和相关 PD 增加的处方模式的确切变化尚不清楚，但这可能是未来研究的主题。结论：DOT/100 PD 中报告的加拿大一家急症护理儿科医院的抗菌药物使用数据是在四年时间内编制的。这些数据可能有助于基准测试。