INTRODUCTION: Monitoring the volume and patterns of use of antimicrobial agents is important in light of antimicrobial resistance.OBJECTIVE: To assess the use of three antimicrobial groups – tetracycline, sulfonamide-trimethoprim and ‘other’ antimicrobials – within Canadian provinces over time.METHODS: Prescription counts from 1995 to 2010 were acquired for the tetracycline and sulfonamide-trimethoprim groups of antimicrobials, and from 2001 to 2010 for the ‘other’ antimicrobial group. Linear mixed models were produced to assess differences among provinces and over time while accounting for repeated measurements. Prescription rate, defined daily dose per 1000 inhabitant-days and defined daily doses per prescription measures for the year 2009 were also compared with those reported by participating European Union countries to determine where Canadian provinces rank in terms of antimicrobial use among these countries.RESULTS: Prescribing of all three groups varied according to province and over time. Tetracycline and sulfonamide-trimethoprim group prescribing were significantly reduced over the study period, by 36% and 61%, respectively. Prescribing of the ‘other’ antimicrobial group increased in all provinces from 2001 to 2010 with the exception of Prince Edward Island, although by varying amounts (10% to 61% increases).DISCUSSION: The overall use of antimicrobials in Canada has dropped from 1995 to 2010, and the tetracycline and sulfonamide-trimethoprim groups have contributed to this decline. The use of the ‘other’ antimicrobials has increased, however. These results may suggest that switches are being made among these groups, particularly among the antimicrobials used to treat urinary tract infections.

中文翻译：

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1995 年至 2010 年加拿大门诊四环素、磺胺甲氧苄氨嘧啶和“其他”抗菌药物使用情况的纵向监测。

简介：鉴于抗微生物药物耐药性，监测抗微生物药物的使用量和使用模式非常重要。目标：评估加拿大各省随时间推移使用三类抗微生物药物——四环素、磺胺甲氧苄氨嘧啶和“其他”抗微生物药物。方法：获得了 1995 年至 2010 年四环素和磺胺-甲氧苄啶组抗菌药物的处方计数，以及 2001 至 2010 年“其他”抗菌药物组的处方计数。生成线性混合模型以评估不同省份之间和随时间推移的差异，同时考虑到重复测量。处方率，还将 2009 年每 1000 个居民日的限定日剂量和每个处方措施的限定日剂量与参与的欧盟国家报告的数据进行比较，以确定加拿大各省在这些国家中抗菌素使用方面的排名。 结果：所有处方三组因省份和时间而异。在研究期间，四环素和磺胺甲氧苄啶组的处方量分别显着减少了 36% 和 61%。从 2001 年到 2010 年，除爱德华王子岛外，所有省份的“其他”抗菌药物组的处方都有所增加，尽管数量不同（增加了 10% 至 61%）。 讨论：加拿大抗菌药物的总体使用量从 1995 年开始下降到 2010 年，而四环素和磺胺甲氧苄啶组也促成了这种下降。然而，“其他”抗微生物剂的使用有所增加。这些结果可能表明这些群体之间正在发生转变，特别是在用于治疗尿路感染的抗菌药物之间。