Myoglianin, the Drosophila homolog of the secreted vertebrate proteins Myostatin and GDF-11, is an important regulator of neuronal modeling, and synapse function and morphology. While Myoglianin suppression during development elicits positive effects on the neuromuscular system, genetic manipulations of myoglianin expression levels have a varied effect on the outcome of performance tests in aging flies. Specifically, Myoglianin preserves jumping ability, has no effect on negative geotaxis, and negatively regulates flight performance in aging flies. In addition, Myoglianin exhibits a tissue-specific effect on longevity, with myoglianin upregulation in glial cells increasing the median lifespan. These findings indicate complex role for this TGF-β-like protein in governing neuromuscular signaling and consequent behavioral outputs and lifespan in adult flies.

Myoglianin是分泌的脊椎动物蛋白Myostatin和GDF-11的果蝇同源物，是神经元建模以及突触功能和形态的重要调节剂。虽然发育过程中的Myoglianin抑制会对神经肌肉系统产生积极影响，但对Myoglianin表达水平的遗传操作对衰老果蝇性能测试的结果产生不同的影响。具体而言，Myoglianin保留跳跃能力，对负地轴方向没有影响，并负面调节衰老果蝇的飞行性能。此外，Myoglianin与Myoglianin相比，对长寿具有组织特异性作用胶质细胞的上调增加了中位寿命。这些发现表明该TGF-β样蛋白在控制神经肌肉信号传导以及成年果蝇的行为输出和寿命中起着复杂的作用。