BACKGROUND At present, whether human cytomegalovirus (HCMV) infection is associated with type 2 diabetes mellitus (T2DM) is debatable. The effect of active HCMV infection on glucose regulation has been poorly studied. Although HCMV infection is correlated with atherosclerosis in cardiovascular disease, the role of HCMV infection in the development of diabetic atherosclerosis in T2DM is unclear and is usually neglected by endocrinologists. The aim of this study was to assess the effects of HCMV infection on glucose regulation and the development of diabetic atherosclerosis in T2DM patients. MATERIAL AND METHODS A total of 222 hospitalized T2DM patients were enrolled. Nested polymerase chain reactions were used to detect HCMV DNA extracted from peripheral blood leukocytes. Quantitative real-time PCR was used to determine viral load. HCMV IgG antibody concentrations were analyzed by chemiluminescence immunoassay. RESULTS HCMV active infection, viral load, and HCMV IgG titers were not correlated with glucose regulation. Binary logistic regression demonstrated that the highest quartile of HCMV IgG concentration (>500 U/ml) was correlated with the incidence of diabetic atherosclerosis (OR: 8.0, 95%CI: 2.3-27.2), and that titer >127 U/ml of HCMV IgG is an independent predictor for the development of diabetic atherosclerosis in T2DM patients (OR: 4.6, 95%CI: 1.9-11.3) after adjustment for all potential confounding factors. CONCLUSIONS Active HCMV infection is unlikely to influence glucose regulation in T2DM. However, HCMV IgG titers are associated with the incidence of diabetic atherosclerosis, and titer >127 U/ml of HCMV IgG might be an independent risk factor for the development of diabetic atherosclerosis in T2DM patients.

中文翻译：

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高人类巨细胞病毒IgG水平与2型糖尿病患者中糖尿病动脉粥样硬化的发生率增加相关。

背景技术目前，人类巨细胞病毒（HCMV）感染是否与2型糖尿病（T2DM）有关还存在争议。主动HCMV感染对葡萄糖调节的影响研究很少。尽管HCMV感染与心血管疾病中的动脉粥样硬化相关，但是HCMV感染在T2DM中糖尿病性动脉粥样硬化发展中的作用尚不清楚，并且通常被内分泌学家所忽略。这项研究的目的是评估HCMV感染对2型糖尿病患者血糖调节和糖尿病动脉粥样硬化发展的影响。材料与方法共有222名住院的T2DM患者入组。巢式聚合酶链反应用于检测从外周血白细胞提取的HCMV DNA。实时定量PCR用于确定病毒载量。通过化学发光免疫测定法分析了HCMV IgG抗体浓度。结果HCMV主动感染，病毒载量和HCMV IgG滴度与葡萄糖调节无关。二元逻辑回归表明，HCMV IgG浓度的最高四分位数（> 500 U / ml）与糖尿病动脉粥样硬化的发生率相关（OR：8.0，95％CI：2.3-27.2），且滴度> 127 U / ml调整所有潜在的混杂因素后，HCMV IgG是T2DM患者糖尿病动脉粥样硬化发展的独立预测因子（OR：4.6、95％CI：1.9-11.3）。结论活动性HCMV感染不太可能影响T2DM中的葡萄糖调节。但是，HCMV IgG滴度与糖尿病动脉粥样硬化的发生有关，且滴度>