BACKGROUNDS N-halamine antibacterial materials have been extensively explored over the past few decades due to their fast inactivation of a broad spectrum of bacterial and rechargeability. Electrospun nanofibers loaded with N-halamines have gained great attention because of their enhanced antibacterial capability induced by the larger specific surface area. The patents on electrospun nanofibers (US20080679694), (CN2015207182871) helped in the method for the preparation of nanofibers. METHODS In this study, a novel N-halamine precursor, 3-(3'-Chloro-propyl)-5,5-dimethylimidazolidine- 2,4-dione(CPDMH), was synthesized. Antimicrobial electrospun Cellulose Acetate (CA) nanofibers were fabricated through impregnating CPDMH as an antimicrobial agent into CA fibers by the bubble electrospinning. The surface morphologies of CA/CPDMH nanofibrous membranes were characterized by Scanning Electron Microscope (SEM). RESULTS The chlorinated fibrous membranes (CA/CPDMH-Cl) exhibited effective antimicrobial activity against 100% of S. aureus and E. coli O157:H7 within 1 min and 5 min, respectively. The CA/CPDMH-Cl nanofibrous membranes showed good storage stability under the dark and excellent durability towards UVA light exposure. Meanwhile, the release of active chlorine from the chlorinated nanofibrous membranes was stable and safe. Besides, the addition of CPDMH could improve the mechanical property, and chlorination did not obviously affect the strength and elongation of the nanofibrous membranes. CONCLUSION CPDMH could endow the electrospun CA nanofibers with powerful, durable and regenerable antimicrobial properties. It will provide a continuous and effective method for health-care relative industrial application.

中文翻译：

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用于抗菌应用的醋酸纤维素纳米纤维膜。

背景技术在过去的几十年中，由于N-卤胺抗菌材料的广泛范围的细菌快速灭活和可充电性，已经对其进行了广泛的研究。负载N-卤胺的静电纺丝纳米纤维由于较大的比表面积而增强了抗菌能力，因此备受关注。关于电纺纳米纤维的专利（US20080679694）（CN2015207182871）帮助了制备纳米纤维的方法。方法在本研究中，合成了一种新型的N-卤胺前体3-（3'-氯丙基）-5,5-二甲基咪唑烷-2,4-二酮（CPDMH）。通过气泡静电纺丝法将作为抗菌剂的CPDMH浸渍到CA纤维中，制成了抗菌电纺醋酸纤维（CA）纳米纤维。CA / CPDMH纳米纤维膜的表面形貌通过扫描电子显微镜（SEM）表征。结果氯化纤维膜（CA / CPDMH-Cl）分别在1分钟和5分钟内对100％的金黄色葡萄球菌和大肠杆菌O157：H7表现出有效的抗菌活性。CA / CPDMH-Cl纳米纤维膜在黑暗中显示出良好的储存稳定性，并且对UVA曝光具有出色的耐久性。同时，从氯化纳米纤维膜释放的活性氯稳定且安全。此外，添加CPDMH可以改善机械性能，氯化对纳米纤维膜的强度和伸长率没有明显影响。结论CPDMH可赋予电纺CA纳米纤维以强大，持久和可再生的抗菌性能。