An approach to solve the limitations of autologous bone grafting procedures in bone injury treatment is to develop bioactive coatings in the implantation system. The objective of this work is to compare the temperature effect on the stability of hydroxyapatite, graphene, and collagen colloidal suspensions to be used as biocompatible and bioactive coatings on a carbon fiber composite surface. Synthesized hydroxyapatite was assessed by X-ray diffraction. Zeta potential at different temperatures was evaluated. Specimens were characterized using scanning electron microscopy and Raman analysis. The results showed that the best hydroxyapatite/graphene ratio was 85/15, while those of the hydroxyapatite/collagen mixtures were 85/15. A hydroxyapatite/graphene/collagen mixture was synthesized based on these results.

中文翻译：

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合成羟基磷灰石及其在生物活性涂料中的应用

解决骨损伤治疗中自体骨移植程序局限性的一种方法是在植入系统中开发生物活性涂层。这项工作的目的是比较温度对羟基磷灰石、石墨烯和胶原胶体悬浮液稳定性的影响，这些悬浮液用作碳纤维复合材料表面上的生物相容性和生物活性涂层。通过 X 射线衍射评估合成的羟基磷灰石。评估了不同温度下的 Zeta 电位。使用扫描电子显微镜和拉曼分析表征样品。结果表明，羟基磷灰石/石墨烯的最佳比例为85/15，而羟基磷灰石/胶原混合物的最佳比例为85/15。基于这些结果合成了羟基磷灰石/石墨烯/胶原混合物。