Cells and tissues are exposed to multiple mechanical stresses during development, tissue homoeostasis and diseases. While we start to have an extensive understanding of the influence of mechanics on cell differentiation and proliferation, how excessive mechanical stresses can also lead to cell death and may be associated with pathologies has been much less explored so far. Recently, the development of new perturbative approaches allowing modulation of pressure and deformation of tissues has demonstrated that compaction (the reduction of tissue size or volume) can lead to cell elimination. Here, we discuss the relevant type of stress and the parameters that could be causal to cell death from single cell to multicellular systems. We then compare the pathways and mechanisms that have been proposed to influence cell survival upon compaction. We eventually describe the relevance of compaction‐induced death in vivo, and its functions in morphogenesis, tissue size regulation, tissue homoeostasis and cancer progression.

中文翻译：

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在压力下死亡：压实诱导的细胞死亡的细胞特征和体内功能

细胞和组织在发育、组织稳态和疾病期间暴露于多种机械应力。虽然我们开始对力学对细胞分化和增殖的影响有了广泛的了解，但迄今为止，对过度机械应力如何也会导致细胞死亡并可能与病理学相关的研究还很少。最近，允许调节压力和组织变形的新微扰方法的发展表明，压实（组织大小或体积的减少）可以导致细胞消除。在这里，我们讨论了相关类型的压力以及可能导致从单细胞到多细胞系统的细胞死亡的参数。然后，我们比较了已提出的影响压实后细胞存活的途径和机制。