Adult-onset Still's disease (AOSD) is a rare multisystem autoinflammatory disorder of unknown etiology. AOSD is generally characterized by high spiking fever, arthralgia or arthritis, skin rash, leukocytosis, and hyperferritinemia. Traditionally, AOSD has been treated with non-steroidal anti-inflammatory drugs, corticosteroids, and immunosuppressants. An increasing number of studies have shown that proinflammatory cytokines, such as interleukin-1β, -18, -6, and tumor necrosis factor-α, play key roles in AOSD and may serve as therapeutic targets. In the current review, we provided insights into the roles of these cytokines in the pathogenesis of AOSD and also provided a commentary on the clinical studies of biologic therapy against AOSD.

中文翻译：

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成人斯蒂尔病的自身炎症发病机制和靶向治疗。

成人斯蒂尔病 (AOSD) 是一种罕见的、病因不明的多系统自身炎症性疾病。AOSD 通常以高热、关节痛或关节炎、皮疹、白细胞增多和高铁蛋白血症为特征。传统上，AOSD 一直用非甾体抗炎药、皮质类固醇和免疫抑制剂治疗。越来越多的研究表明，促炎细胞因子，如白细胞介素-1β、-18、-6​​ 和肿瘤坏死因子-α，在 AOSD 中起关键作用，可作为治疗靶点。在本次审查中，我们提供了对这些细胞因子在 AOSD 发病机制中的作用的见解，并对生物治疗 AOSD 的临床研究进行了评论。