Functional reprogramming of a differentiated cell toward pluripotent cell may have long-term applications in numerous aspects, especially in regenerative medicine. Evidences accumulating from recent studies suggest that cellular extracts from stem cells or pluripotent cells can induce epigenetic reprogramming and facilitate pluripotency in otherwise highly differentiated cell types. Epigenetic reprogramming using cellular extracts has gained increasing attention and applied to recognize the functional factors, acquire the target cell types, and explain the mechanism of reprogramming. Now, more and more researches have proved that cellular extract treatment is an important strategy of cellular reprogramming. Thus, this review mainly focused on the progresses and potential mechanisms in epigenetic reprogramming using cellular extracts.

中文翻译：

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细胞提取物对表观遗传重编程的影响。

分化的细胞向多能细胞的功能重编程可能在许多方面具有长期应用，尤其是在再生医学中。最近的研究积累的证据表明，干细胞或多能细胞的细胞提取物可以诱导表观遗传重编程，并促进原本高度分化的细胞类型的多能性。使用细胞提取物进行表观遗传重编程受到了越来越多的关注，并被用于识别功能因子，获得靶细胞类型以及解释重编程的机制。现在，越来越多的研究证明细胞提取物处理是细胞重编程的重要策略。因此，这篇综述主要集中在利用细胞提取物进行表观遗传重编程的进展和潜在机制上。