We report here the light and electron microscopic neuropathology of the 139A-H strain of scrapie passaged in Syrian golden hamsters. The general neuropathological picture consisted of the spongiform change and severe astrocytic gliosis. The topography of prion protein (PrP) was variable, the highest signal was observed in the CA2-molecular layer, CA1-pyramidal and entorhinal cortex. The electron microscopy consisted of: 1. Spongiform vacuoles - these are always membrane bound and contain secondary vacuoles (i.e. membrane-bound compartments or vesicles within vacuoles) and curled membraned fragments. 2. Tubulovesicular structures (TVS) - these are vesicular structures of approximate 27 nm in diameter within neuronal processes - i.e. axonal terminal or dendrites. TVS are smaller and of higher electron density than synaptic vesicles. The significance of TVS remains unknown. 3. Dystrophic neurites. Dendrites or axonal preterminals and terminals filled with electron-dense bodies, including small autophagic vacuoles. 4. Apoptotic cell nuclei. 5. "Whorls", concentric arrays of membranes were visible. A significance of those structures is unknown.

中文翻译：

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在仓鼠中传播的瘙痒病的139A-H菌株的光电子显微镜研究。

我们在这里报告在叙利亚金仓鼠中传播的瘙痒病139A-H株的光和电子显微神经病理学。总体神经病理学特征包括海绵状变化和严重的星形胶质细胞胶质增生。ion病毒蛋白（PrP）的形貌是可变的，在CA2分子层，CA1锥体和内嗅皮层中观察到最高信号。电子显微镜包括：1.海绵状液泡-总是与膜结合，并包含次级液泡（即液膜内的膜结合隔室或囊泡）和卷曲的膜碎片。2.肾小管结构（TVS）-这些是神经元过程中直径约27 nm的囊状结构-即轴突末端或树突。TVS比突触小泡小，电子密度高。TVS的意义仍然未知。3.营养不良的神经突。树突或轴突的前末端和充满电子致密体的末端，包括小的自噬泡。4.凋亡细胞核。5.“漩涡”，可见同心的膜阵列。这些结构的重要性未知。