Argyrophilic grain disease (AGD) is a sporadic tauopathy and actually the second most frequent cause of dementia after Alzheimer's disease. Patients can present with slowly progressive cognitive decline as well as psychiatric manifestations such as depression. Definite diagnosis of AGD can only be made by post-mortem examination of the brain. Neuropathological features include argyrophilic grains in limbic areas along with oligodendroglial coiled bodies in hippocampal and amygdaloid white matter, and ballooned neurons in the amygdala. AGD, however, can often be overlooked and missed on neuropathologic examination as there are actually no specific clinical manifestations that would be considered highly suggestive of AGD. Thus, it is not uncommon to find neuropathological features of AGD in patients who do not present with any apparent neurological manifestations. The aim of this review is to provide an overview of what is currently known about AGD as well as raise its awareness among both neurologists and neuropathologists who may otherwise overlook this interesting tauopathy. We believe that patients above the age of 60 years should undergo post-mortem screening for AGD to avoid missed opportunity for diagnosis and enable future clinicopathological studies.

中文翻译：

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嗜银粒病：一种被忽视的牛磺酸病的临床病理学评论。

嗜银粒病（AGD）是一种偶发性牛磺酸病，实际上是继阿尔茨海默氏病之后第二大最常见的痴呆病因。患者可表现出缓慢的进行性认知下降以及精神病表现，例如抑郁。只能通过验尸检查才能对AGD进行明确的诊断。神经病理学特征包括边缘区域的嗜银颗粒，海马和杏仁核白质中的少突神经胶质盘绕体以及杏仁核中呈气球状的神经元。然而，在神经病理学检查中，AGD常常被忽视和遗漏，因为实际上没有特定的临床表现被认为是高度提示AGD的。从而，在没有任何明显神经系统表现的患者中发现AGD的神经病理学特征并不罕见。这篇综述的目的是概述当前关于AGD的知识，并提高神经科医生和神经病理学家的认识，否则他们可能会忽略这种有趣的tauopathy。我们认为，年龄在60岁以上的患者应进行AGD验尸检查，以避免错过诊断机会，并可以进行进一步的临床病理学研究。