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Modern Assay Techniques for Cancer Drugs: Electroanalytical and Liquid Chromatography Methods.
Critical Reviews in Analytical Chemistry ( IF 4.2 ) Pub Date : 2019-01-01 , DOI: 10.1080/10408347.2018.1527206
Sevinc Kurbanoglu 1 , Nurgul K Bakirhan 2 , Mehmet Gumustas 3 , Sibel A Ozkan 1
Affiliation  

In the past decades, patients who have chemotherapy treatment have considerably increased number. At this point, the development of rapid precise, and reliable methods are very important to analyze cancer drugs from their dosage forms, animals or human biological samples. Among all the analytical methods, electrochemical methods hold an important position with their unique properties such as specificity in the biological recognition process, fast response, and their reliability and do not need a pretreatment process. Chromatographic methods are also used in a wide range of analytical applications for the analyses of anticancer drugs. The power of chromatography comes from its ability to separate a mixture of analytes and determination of their concentrations. Chromatographic techniques can mainly be divided into gas, liquid, and supercritical fluid chromatography. In the frame of this information, this review is aimed to provide basic principles of electroanalytical and high-performance liquid chromatography methods for the analysis of cancer drugs. In addition, some selected applications for electrochemistry-related techniques and high-performance liquid chromatography, for the determination of anti-cancer pharmaceuticals published in the last five years are also discussed.

中文翻译:

癌症药物的现代检测技术:电分析和液相色谱方法。

在过去的几十年中,接受化学疗法治疗的患者数量大大增加。在这一点上,快速精确,可靠方法的发展对于从其剂型,动物或人类生物样品中分析癌症药物非常重要。在所有的分析方法中,电化学方法以其独特的性能(例如在生物识别过程中的特异性,快速的响应以及其可靠性)而占有重要的地位,并且不需要预处理过程。色谱方法还广泛用于分析抗癌药物的分析应用中。色谱法的强大之处在于它能够分离出各种分析物并确定其浓度。色谱技术主要可分为气体,液体,和超临界流体色谱。在此信息的框架内,本综述旨在提供用于癌症药物分析的电分析和高效液相色谱方法的基本原理。此外,还讨论了电化学相关技术和高效液相色谱法在最近五年中用于确定抗癌药物的某些选定应用。
更新日期:2018-12-29
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