Macrophages M2 polarization have been taken as an anti-inflammatory progression during inflammation. Natural plant-derived products, with potential therapeutic and preventive activities against inflammatory diseases, have received increasing attention in recent years because of their whole regulative effects and specific pharmacological activities. However, the molecular mechanisms about how different kinds of natural compounds regulate macrophages polarization still unclear. Therefore, in the current review, we summarized the detailed research progress on the active compounds derived from herbal plants with regulating effects on macrophages, especially M2 polarization. These natural occurring compounds including flavonoids, terpenoids, glycosides, lignans, coumarins, alkaloids, polyphenols and quinones. In addition, we extensively discussed the cellular mechanisms underlying the M2 polarization for each compound, which could provide potential therapeutic strategies aiming macrophages M2 polarization.

巨噬细胞M2极化已被认为是炎症过程中的消炎进程。天然植物来源的产品具有潜在的针对炎性疾病的治疗和预防活性，由于其整体调节作用和特定的药理活性，近年来受到越来越多的关注。然而，关于不同种类的天然化合物如何调节巨噬细胞极化的分子机制仍不清楚。因此，在当前的综述中，我们总结了对草药植物中的活性化合物具有调节作用的详细研究进展，这些活性化合物对巨噬细胞，尤其是M2极化具有调节作用。这些天然存在的化合物包括类黄酮，萜类化合物，糖苷，木脂素，香豆素，生物碱，多酚和醌。此外，