Yersinia pestis, a bacterial pathogen that causes sylvatic plague, is present in the prairie dogs (Cynomys spp.) of North America. Epizootics of sylvatic plague through transmission in vectors (fleas) commonly completely extirpate colonies of prairie dogs. Wildlife managers employ a wide variety of insecticidal treatments to suppress plague and conserve prairie dog colonies. I compiled and statistically compared the available literature describing methods of plague control and their relative effectiveness in managing plague outbreaks by using meta‐analyses. Natural log response ratios were used to calculate insecticide‐induced vector mortality and vaccine‐conferred survival increases in prairie dogs in 37 publications. Further, subgroupings were used to explore the most effective of the available vector suppression insecticides and plague suppression vaccines. After accounting for the type of treatment used and the method by which it was applied, I observed plague reduction through use of both insecticides and vaccines. Insecticides resulted in a significant reduction of the abundance of vectors by 91.34% compared to non‐treated hosts (p<0.0001). Vaccines improved survival of prairie dog hosts by 4.00% (p<0.0001) compared to control populations. The use of insecticides such as deltamethrin and carbaryl is recommended to stop actively spreading epizootics, and dual antigen oral vaccines to initially suppress outbreaks.

中文翻译：

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鼠疫鼠疫管理和草原犬鼠-荟萃分析。

鼠疫耶尔森氏菌是引起鼠疫的细菌病原体（Cynomysspp。）。通过传染媒介（蚤）传播的鼠疫鼠疫通常完全消灭草原犬鼠的菌落。野生动物管理人员采用多种杀虫方法来抑制鼠疫并保护草原犬鼠的殖民地。我汇编并进行了统计比较，这些文献描述了鼠疫控制方法及其通过荟萃分析在控制鼠疫暴发中的相对有效性。在37种出版物中，使用自然对数响应比来计算杀虫剂引起的媒介物死亡率和草原犬只的疫苗赋予的存活率。此外，使用亚组来探索最有效的可用载体抑制杀虫剂和鼠疫抑制疫苗。在考虑了所使用的治疗类型和应用方法之后，我观察到通过同时使用杀虫剂和疫苗可以减少鼠疫。与未处理的宿主相比，杀虫剂可使载体的丰度大大降低了91.34％（p <0.0001）。与对照种群相比，疫苗将草原犬宿主的存活率提高了4.00％（p <0.0001）。建议使用杀虫剂（例如溴氰菊酯和西维因）来停止积极传播动物流行病，并建议使用双抗原口服疫苗来初步抑制疾病爆发。