The aim of this study was to evaluate the possible effects of endometriosis on early embryo development, by comparing the morphokinetic development of embryos obtained from women with clinically confirmed endometriosis with the ones obtained from tubal factor infertility cases. A total of 82 cycles/patients including 53 cycles with endometriosis and 29 cycles with tubal factor infertility were evaluated. A total of 439 embryos were scored for embryo morphokinetics. Age, body mass index, fertilization rates were similar within the groups. However, the number of previous ART trials was found to be higher (p < 0.05) in the study group. Also, the number of retrieved oocytes and M2 oocytes were found to be significantly lower in patients with endometriosis (p < 0.01). The duration of the first cell cycle (ECC1) and S2 (the time between t3 and t4) displayed significant distortions compared with embryos in the control group. All other analyzed early morphokinetic parameters (t2, t3, t4, t5, t6, t7, t8) and duration of events (VP, cc2a, ECC2, ECC3, S3) showed similar values between study and control groups, respectively. In the light of these findings, it is apparent that endometriosis predominantly affects the duration of the early morphokinetic events and cell cycles.

这项研究的目的是通过比较临床确诊为子宫内膜异位症的妇女与输卵管因素不育病例获得的胚的形态动力学发育来评估子宫内膜异位症对早期胚胎发育的可能影响。总共评估了82个周期/患者，包括53个子宫内膜异位症周期和29个输卵管因素不孕症周期。总共对439个胚胎进行了胚胎形态动力学评估。各组之间的年龄，体重指数，受精率相似。然而，在研究组中发现先前的抗逆转录病毒治疗试验的次数更高（p <0.05）。此外，发现子宫内膜异位症患者的回收卵母细胞和M2卵母细胞数量显着降低（p<0.01）。与对照组的胚胎相比，第一个细胞周期（ECC1）和S2的持续时间（t3和t4之间的时间）显示出明显的变形。所有其他分析的早期形态动力学参数（t2，t3，t4，t5，t6，t7，t8）和事件持续时间（VP，cc2a，ECC2，ECC3，S3）在研究组和对照组之间分别显示相似的值。根据这些发现，很明显子宫内膜异位症主要影响早期形态动力学事件和细胞周期的持续时间。