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Multidrug Therapy for HIV Infection: Dynamics of Immune System
Acta Biotheoretica ( IF 1.4 ) Pub Date : 2018-12-04 , DOI: 10.1007/s10441-018-9340-0
Deepmala Kamboj 1 , M D Sharma 2
Affiliation  

A mathematical model of the dynamics of the immune system is considered to illustrate the effect of its response to HIV infection, i.e. on viral growth and on T-cell dynamics. The specific immune response is measured by the levels of cytotoxic lymphocytes in a human body. The existence and stability analyses are performed for infected steady state and uninfected steady state. In order to keep infection under control, roles of drug therapies are analyzed in the presence of efficient immune response. Numerical simulations are computed and exhibited to illustrate the support of the immune system to drug therapies, so as to ensure the decay of infection and to maintain the level of healthy cells.

中文翻译:

HIV 感染的多药治疗:免疫系统动力学

免疫系统动力学的数学模型被认为可以说明其对 HIV 感染的反应的影响,即对病毒生长和 T 细胞动力学的影响。特异性免疫反应是通过人体内细胞毒性淋巴细胞的水平来衡量的。对感染稳态和未感染稳态进行存在性和稳定性分析。为了控制感染,在有效免疫反应存在的情况下分析药物疗法的作用。计算并展示数值模拟以说明免疫系统对药物治疗的支持,从而确保感染的衰减并维持健康细胞的水平。
更新日期:2018-12-04
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