ABSTRACT Background: Electromagnetic fields (EMF) created by mobile phones during communication have harmful effects on different organs. Objectives: To explore the effects of exposure to EMF of mobile phones for different durations on hematological parameters and serum hepcidin in male albino rats. Methods: Three groups of eight rats: Sham group: rats were exposed to a mobile phone while it was switched off, Experimental group I: rats were exposed to microwave radiation from a mobile phone at 9 am for 30 min. Experimental group II: rats were exposed to microwave radiations from a mobile phone at 9 am for an hour. In all groups, the exposure was conducted daily for a total period of 5 months, followed by estimation of serum hepcidin, total leukocyte count (TLC), interleukin 6 (IL6), serum iron, serum ferritin, plasma hemoglobin (Hb), hematocrit value (Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), unsaturated iron binding capacity (UIBC), total iron binding capacity (TIBC) and 1.25 dihydroxycholecalciferol levels. Results: In Experimental group II, there was a significant increase in serum hepcidin, TLC, IL6 and serum ferritin; however, serum iron, TIBC, UIBC, 1.25 dihydroxycholecalciferol, plasma Hb, Hct, MCV and MCH were significantly lower in comparison to sham-exposed group. In Experimental group I, there was a significant increase in serum hepcidin, IL6 and TLC, along with non-significant changes in the remaining studied parameters in comparison to the sham-exposed group. Conclusion: Chronic exposure to EMF from mobile phones increases hepcidin level with subsequent impairment of iron parameters, in addition to negatively affecting both UIBC and TIBC.

中文翻译：

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手机电磁场暴露对雄性白化大鼠血清铁调素和铁状态的影响

摘要背景： 手机在通信过程中产生的电磁场 (EMF) 会对不同器官产生有害影响。目的：探讨不同时间手机电磁场暴露对雄性白化大鼠血液学参数和血清铁调素的影响。方法：三组8只大鼠：假手术组：大鼠在关机状态下接触手机，实验组I：大鼠在上午9点接触手机的微波辐射30分钟。实验组II：大鼠在上午9点暴露于手机的微波辐射1小时。在所有组中，每天进行暴露，共 5 个月，然后估计血清铁调素、总白细胞计数 (TLC)、白细胞介素 6 (IL6)、血清铁、血清铁蛋白、血浆血红蛋白 (Hb)、血细胞比容值 (Hct)、平均红细胞体积 (MCV)、平均红细胞血红蛋白 (MCH)、不饱和铁结合能力 (UIBC)、总铁结合能力 (TIBC) 和 1.25 二羟胆钙化醇水平。结果：实验Ⅱ组血清铁调素、TLC、IL6、血清铁蛋白明显升高；然而，与假暴露组相比，血清铁、TIBC、UIBC、1.25 二羟胆钙化醇、血浆 Hb、Hct、MCV 和 MCH 显着降低。在实验组 I 中，与假暴露组相比，血清铁调素、IL6 和 TLC 显着增加，其余研究参数没有显着变化。结论：长期暴露于手机 EMF 会增加铁调素水平，随后铁参数受损，