当前位置: X-MOL 学术Crit. Rev. Anal. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
A Review: New Trends in Electrode Systems for Sensitive Drug and Biomolecule Analysis.
Critical Reviews in Analytical Chemistry ( IF 4.2 ) Pub Date : 2019-05-20 , DOI: 10.1080/10408347.2019.1615406
Goksu Ozcelikay 1 , Leyla Karadurmus 1, 2 , S Irem Kaya 1 , Nurgul K Bakirhan 3 , Sibel A Ozkan 1
Affiliation  

Drug and biomolecule analysis with high precision, fast response, not expensive, and user-friendly methods have been very important for developing technology and clinical applications. Electrochemical methods are highly capable for assaying the concentration of electroactive drug or biomolecule and supply excellent knowledge concerning its physical and chemical properties such as electron transfer rates, diffusion coefficients, electron transfer number, and oxidation potential. Electrochemical methods have been widely applied because of their accuracy, sensitivity, cheapness, and can applied on-site determinations of various substances. The progress on electronics has allowed developing reliable, more sensitive and less expensive instrumentations, which have significant contribution in the area of drug development, drug and biomolecule analysis. The developing new sensors for electrochemical analysis of these compounds have growing interest in recent years. Screen-printed based electrodes have a great interest in electrochemical analysis of various drugs and biomolecules due to their easy manufacturing procedure of the electrode allow the transfer of electrochemical laboratory experiments for disposable on-site analysis of some compounds. Paper based electrodes are also fabricated by new technology. They can be preferred due to their easy, cheap, portable, disposable, and offering high sensitivity properties for many application field such as environmental monitoring, food quality control, clinical diagnosis, drug, and biomolecules analysis. In this review, the recent electrochemical drug and biomolecule (DNA, RNA, µRNA, Biomarkers, etc.) studies will be presented that involve new trend disposable electrodes.

中文翻译:

综述:用于敏感药物和生物分子分析的电极系统的新趋势。

高精度,快速响应,不昂贵且用户友好的方法的药物和生物分子分析对于开发技术和临床应用非常重要。电化学方法非常有能力分析电活性药物或生物分子的浓度,并提供有关其物理和化学性质(如电子传输速率,扩散系数,电子传输数和氧化电位)的出色知识。电化学方法由于其准确性,灵敏性,便宜性而被广泛应用,并且可以应用于各种物质的现场测定。电子学的进步使人们能够开发出可靠,更灵敏,更便宜的仪器,这些仪器在药物开发,药物和生物分子分析领域都做出了重大贡献。近年来,开发用于这些化合物的电化学分析的新型传感器的兴趣日益浓厚。基于丝网印刷的电极对各种药物和生物分子的电化学分析具有极大的兴趣,因为它们的电极易于制造,可以将电化学实验室实验转移到一些化合物的一次性现场分析中。纸基电极也是通过新技术制造的。由于它们容易,便宜,便携式,可抛弃,并且在许多应用领域(例如环境监测,食品质量控制,临床诊断,药物和生物分子分析)提供高灵敏度特性,因此它们是首选。在这篇评论中,最近的电化学药物和生物分子(DNA,RNA,µRNA,生物标志物等)
更新日期:2020-04-20
down
wechat
bug