Genetic variants on chromosome 9p21 confer risks of cerebral infarction in the Chinese population: a meta-analysis.,International Journal of Immunopathology and Pharmacology

当前位置： X-MOL 学术 › Int. J. Immunopathol. Pharmacol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Genetic variants on chromosome 9p21 confer risks of cerebral infarction in the Chinese population: a meta-analysis.
International Journal of Immunopathology and Pharmacology ( IF 3.0 ) Pub Date : 2019-05-06 , DOI: 10.1177/2058738419847852
Ji-Xiang Chen ₁ , Jing Liu ₂ , Feng Hu ₃ , Ying Bi ₁ , Man Li ₁ , Lei Zhao ₄

Affiliation

Ischemic stroke (IS) is the leading cause of disability. Researchers have demonstrated that IS is more a multifactorial disorder than a single-factor disease. At present, no consistent conclusions have been reached on susceptibility loci for IS on chromosome 9p21. We conducted this meta-analysis to verify whether genetic loci on chromosome 9p21 reported domestically and abroad could be responsible for IS in Chinese populations. We analyzed data from eight studies that covered a total of 9756 individuals with Chinese ancestry comprising 4254 cases and 5502 controls. Each of the four reported susceptibility loci (rs2383206, rs2383207, rs10757274, and rs10757278) was analyzed separately. The odds ratios (ORs) of rs2383206 and rs10757274 were 1.09 (95% confidence interval (CI): 1.02-1.06, P = 0.01) and 1.09 (95% CI: 1.01-1.17, P = 0.03), respectively. For rs2383207, OR value was 0.91 (95% CI: 0.84-0.98, P = 0.01). No statistical association was identified for rs10757278. We have verified previous associations for IS in Chinese populations on chromosome 9p21. Loci rs2383206 and rs10757274 may increase susceptibility to IS. Mutation at locus rs2383207 may be beneficial. However, we are unable to identify any association between rs10757278 and IS.

更新日期：2019-11-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11