Objective: Investigate Vitamin D₃ (VD₃) effect on the Acetylcholinesterase (AChE), oxidative damage and behavioral tests in animals subjected to Intracerebroventicular injection of Streptozotocin (ICV-STZ) simulating a Sporadic Dementia of Alzheimer's Type (SDAT) and treated with VD₃ (21 days).

Methods: Animals were divided into eight groups: Vehicle, VD12.5 μg/kg, VD42 μg/kg, VD125 μg/kg, STZ, STZ+VD12.5 μg/kg, STZ+VD42 μg/kg, STZ+VD125 μg/kg.

Results: VD₃ prevented the increase in AChE in groups of VD42 µg/kg and VD125 µg/kg; in AChE of synaptossomes and TBARS levels prevented the increase in group VD125 µg/kg; in ROS levels there was not a significant difference; for the Carbonyl Content all doses prevented the increase. Total Thiols prevent the decrease in VD42 µg/kg and VD125 µg/kg, and Reduced Glutathione prevented the decrease in VD125 µg/kg, Oxidized Glutathione prevented the increase in VD125 µg/kg. In relation to behavioral tests, the VD₃ prevented the increase in time to find (days 2 and 3), in the time to find the platform (day 3) and in time spent in the quadrant (day 2). However, in relation to crossings there was not difference in groups. These results indicated the therapeutic effect of the VD₃ in model of STZ in rats.

目的：研究维生素 D ₃ (VD ₃ ) 对模拟阿尔茨海默型散发性痴呆 (SDAT) 并接受 VD 治疗的动物脑室内注射链脲佐菌素 (ICV-STZ) 的乙酰胆碱酯酶 (AChE)、氧化损伤和行为测试的影响₃（21 天）。

方法：将动物分为八组：媒介物、VD12.5 μg/kg、VD42 μg/kg、VD125 μg/kg、STZ、STZ+VD12.5 μg/kg、STZ+VD42 μg/kg、STZ+VD125 μg /公斤。

结果： VD ₃抑制了 VD42 µg/kg 组和 VD125 µg/kg 组中 AChE 的升高；突触体的 AChE 和 TBARS 水平阻止了 VD125 µg/kg 组的增加；ROS水平没有显着差异；对于羰基含量，所有剂量都阻止了增加。总硫醇可防止 VD42 µg/kg 和 VD125 µg/kg 的下降，还原型谷胱甘肽可防止 VD125 µg/kg 的下降，氧化型谷胱甘肽可防止 VD125 µg/kg 的增加。在行为测试方面，VD ₃阻止了寻找时间（第 2 天和第 3 天）、寻找平台的时间（第 3 天）和在象限中花费的时间（第 2 天）的增加。然而，就交叉而言，各组之间没有差异。_{这些结果表明VD 3}对大鼠STZ 模型的治疗作用。