OBJECTIVES Inflammation and apoptosis play a critical role in the pathological progress of traumatic brain injury (TBI). Isoliquiritigenin is a bioactive component extracted from licorice roots, which possesses anti-inflammatory and anti-apoptotic properties. This study aims to investigate the potential effects of isoliquiritigenin on neuroinflammation in a rat model of TBI. METHODS The SH-SY5Y cells were subjected to cell injury induced by shear stress and the effect of isoliquiritigenin on cell apoptosis was measured. Male rats received a controlled cortical impact to induce TBI and were then treated with isoliquiritigenin (20 mg/kg). Brain edema and contusion volume were measured to assess brain damage. Morris water maze, the beam-balance test, and the beam-walk test were performed to evaluate the cognitive and motor functions. RESULTS Levels of proinflammatory cytokines and apoptotic regulators were measured. Results showed that isoliquiritigenin reduced shear stress-induced cell apoptosis in vitro. In young rats subjected to TBI, treatment of isoliquiritigenin reduced brain damage and attenuated motor and cognitive impairments. Isoliquiritigenin also reduced the level of proinflammatory cytokines and Bax and increased Bcl-2 and Bcl-xL in TBI rats. CONCLUSIONS These findings suggest that isoliquiritigenin possesses beneficial effects in TBI by inhibiting inflammation and apoptosis.

中文翻译：

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异quiritigeninin减轻年轻大鼠外伤性脑损伤中的神经炎症。

目的炎症和细胞凋亡在脑外伤（TBI）的病理过程中起关键作用。异寡糖原蛋白是从甘草根中提取的一种生物活性成分，具有抗炎和抗凋亡的特性。这项研究的目的是调查异黄体生成素对TBI大鼠模型中神经炎症的潜在影响。方法对SH-SY5Y细胞进行剪应力诱导的细胞损伤，并测定异黄体皂苷元对细胞凋亡的影响。雄性大鼠受到可控的皮层撞击以诱导TBI，然后用异黄体生成素（20 mg / kg）治疗。测量脑水肿和挫伤体积以评估脑损伤。进行莫里斯水迷宫，束平衡测试和束步测试以评估认知和运动功能。结果测量了促炎细胞因子和凋亡调节剂的水平。结果表明，异寡糖原蛋白减少体外切应力诱导的细胞凋亡。在接受TBI的幼鼠中，异黄体生成素的治疗减少了脑损伤，并减轻了运动和认知障碍。异黄体生成素还降低了TBI大鼠的促炎细胞因子和Bax水平，并增加了Bcl-2和Bcl-xL。结论这些发现表明异黄体生成素通过抑制炎症和凋亡在TBI中具有有益作用。异黄体生成素还降低了TBI大鼠的促炎细胞因子和Bax水平，并增加了Bcl-2和Bcl-xL。结论这些发现表明异黄体生成素通过抑制炎症和凋亡在TBI中具有有益作用。异黄体生成素还降低了TBI大鼠的促炎细胞因子和Bax水平，并增加了Bcl-2和Bcl-xL。结论这些发现表明异黄体生成素通过抑制炎症和凋亡在TBI中具有有益作用。