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Centriole inheritance.
Prion ( IF 1.9 ) Pub Date : 2008-01-12 , DOI: 10.4161/pri.2.1.5064
Patricia G Wilson 1
Affiliation  

Early cell biologists perceived centrosomes to be permanent cellular structures. Centrosomes were observed to reproduce once each cycle and to orchestrate assembly a transient mitotic apparatus that segregated chromosomes and a centrosome to each daughter at the completion of cell division. Centrosomes are composed of a pair of centrioles buried in a complex pericentriolar matrix. The bulk of microtubules in cells lie with one end buried in the pericentriolar matrix and the other extending outward into the cytoplasm. Centrioles recruit and organize pericentriolar material. As a result, centrioles dominate microtubule organization and spindle assembly in cells born with centrosomes. Centrioles duplicate in concert with chromosomes during the cell cycle. At the onset of mitosis, sibling centrosomes separate and establish a bipolar spindle that partitions a set of chromosomes and a centrosome to each daughter cell at the completion of mitosis and cell division. Centriole inheritance has historically been ascribed to a template mechanism in which the parental centriole contributed to, if not directed, assembly of a single new centriole once each cell cycle. It is now clear that neither centrioles nor centrosomes are essential to cell proliferation. This review examines the recent literature on inheritance of centrioles in animal cells.

中文翻译:

中心粒继承。

早期的细胞生物学家认为中心体是永久性的细胞结构。观察到中心体在每个循环中繁殖一次,并协调组装一个瞬时有丝分裂装置,在细胞分裂完成时将染色体和中心体分离到每个子代。中心体由一对埋在复杂的中心粒周围基质中的中心粒组成。细胞中的大部分微管一端埋在中心体周围基质中,另一端向外延伸到细胞质中。中心粒招募和组织中心粒周围的材料。因此,中心粒在带有中心体的细胞中支配着微管组织和纺锤体组装。在细胞周期中,中心粒与染色体一起复制。在有丝分裂开始时,同胞中心体分开并建立一个双极纺锤体,在有丝分裂和细胞分裂完成时将一组染色体和一个中心体分配给每个子细胞。中心粒遗传历来被归因于一种模板机制,在这种机制中,父母中心粒有助于(如果不是定向的话)每个细胞周期一次组装一个新的中心粒。现在很清楚,中心粒和中心体都不是细胞增殖所必需的。这篇综述审查了最近关于动物细胞中心粒遗传的文献。每个细胞周期组装一个新的中心粒。现在很清楚,中心粒和中心体都不是细胞增殖所必需的。这篇综述审查了最近关于动物细胞中心粒遗传的文献。每个细胞周期组装一个新的中心粒。现在很清楚,中心粒和中心体都不是细胞增殖所必需的。这篇综述审查了最近关于动物细胞中心粒遗传的文献。
更新日期:2019-11-01
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