Telomerase is a ribonucleoprotein that directs the synthesis of telomeric sequence. It is detected in majority of malignant tumors, but not in most normal somatic cells. Because telomerase plays a critical role in cell immortality and tumor formation, it has been one of the targets for anti-cancer and regeneration drug development. In this review, we will discuss therapeutic approaches based mainly on small molecules that have been developed to inhibit telomerase activity, modulate telomerase expression, and telomerase directed gene therapy.

中文翻译：

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端粒和端粒酶作为抗癌和再生疗法的靶标。

端粒酶是指导端粒序列合成的核糖核蛋白。在大多数恶性肿瘤中都检测到了它，但是在大多数正常的体细胞中却没有检测到它。由于端粒酶在细胞永生和肿瘤形成中起关键作用，因此它已成为抗癌和再生药物开发的目标之一。在这篇综述中，我们将讨论主要基于抑制端粒酶活性，调节端粒酶表达和端粒酶定向基因治疗的小分子的治疗方法。